DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG5568 and CMR2

DIOPT Version :9

Sequence 1:	NP_647992.1	Gene:	CG5568 / 38658	FlyBaseID:	FBgn0035641	Length:	545	Species:	Drosophila melanogaster
Sequence 2:	NP_014736.1	Gene:	CMR2 / 854260	SGDID:	S000005619	Length:	1648	Species:	Saccharomyces cerevisiae

Alignment Length:	439	Identity:	88/439 - (20%)
Similarity:	152/439 - (34%)	Gaps:	137/439 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly    98 LTTHLTALAYACFFNGTPYHALHTEYEQSAIERLF---GITKPRL-IFCDGDEFEKVQAATKGLQ 158
            |:.||:.|...         ||..||  :.||..:   |..||:| :.|.|.::..
Yeast   921 LSEHLSKLRKM---------ALQEEY--AMIEPAYRNGGPVKPKLALQCSGVDYRD--------- 965

  Fly   159 VQIVTMRNHP--AGILRIQDILTTPVEMNFRPVRLKDGTDQLLAILSSSGTSGLPKAVTISN--- 218
             :.|..|:|.  .....|.:||...:..........|||:..|...|:|..:.:.|.|:.::
Yeast   966 -ESVDTRSHTKLTDFKSILEILEWRISNYGNETAFSDGTNTNLVNSSASNDNNVHKKVSWASFGK 1029

  Fly   219 -----SHQIIGSFLPV---DSSIIQYNPNTLDWASGITMTI--NAAVFSLTSIIED-CDFDPANL 272
                 ..:|:||.:|:   |..||... |::::.:.|...:  |..|..|.|:.|. .:.|...|
Yeast  1030 IVAGFLKKIVGSKIPLKHGDPIIIMCE-NSVEYVAMIMACLYCNLLVIPLPSVKESVIEEDLKGL 1093

  Fly   273 CGLIEKYRISMVFVSSSQLAMLSN------CPEFYAADLSSVKYFFYGGSNCSLEV---QNKIRS 328
            ..:|:.|::..|||.:...::|::      |.:.|.:.:..:..|....:..:|.|   :|.::.
Yeast  1094 VNIIQSYKVKRVFVDAKLHSLLNDNNVVNKCFKKYKSLIPKITVFSKVKTKNALTVSMFKNVLKQ 1158

  Fly   329 RLS---------NEC---VNFSYTLTE-----LNSPGCLNFNFDEKPNSVGRPVRGIQIKIVNEL 376
            :..         ..|   ||..|.:|.     :.....||.:                 |||.|.
Yeast  1159 KFGAKPGTRIGMTPCVVWVNTEYDVTSNIHVTMTHSSLLNAS-----------------KIVKET 1206

  Fly   377 GEAQGPNVVGEICFNNGQKWPGYYKNPEETKKMQDSENWFHTGDLGYM----------------- 424
            .:.:..:.:..||                          .||..||:|
Yeast  1207 LQLRNNSPLFSIC--------------------------SHTSGLGFMFSCLLGIYTGASTCLFS 1245

  Fly   425 ------DEDGYLFIIDRL--KDM-LKYQTIMYYPSEIESVIAEMPNVVE 464
                  |...:|..:..|  ||: ||.:|:........|:|....|..|
Yeast  1246 LTDVLTDPKEFLIGLQNLNVKDLYLKLETLYALLDRASSLIEGFKNKKE 1294

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5568	NP_647992.1	CaiC	35..540	CDD:223395	88/439 (20%)
CG5568	NP_647992.1	Firefly_Luc_like	55..530	CDD:213279	88/439 (20%)
CMR2	NP_014736.1	DMAP_binding	5..121	CDD:368923
		AFD_class_I	179..893	CDD:418409
		Dip2	1004..1626	CDD:341231	63/335 (19%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0318
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900