DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG5568 and PCS60

DIOPT Version :9

Sequence 1:	NP_647992.1	Gene:	CG5568 / 38658	FlyBaseID:	FBgn0035641	Length:	545	Species:	Drosophila melanogaster
Sequence 2:	NP_009781.3	Gene:	PCS60 / 852523	SGDID:	S000000426	Length:	543	Species:	Saccharomyces cerevisiae

Alignment Length:	476	Identity:	104/476 - (21%)
Similarity:	186/476 - (39%)	Gaps:	108/476 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly   103 TALAYACFFNGTPYHALHTEYEQSAIERLFGITKPRL---IFCDGDEFEKVQAATKGLQVQIVTM 164
            :|..:.||.                :|..|..|:.|:   |:...|.:::|
Yeast   130 SASTFGCFI----------------VELAFDATRFRVEYDIYSPEDNYKRV-------------- 164

  Fly   165 RNHPAGILRIQDILTTPVEMNFRPVRLKD--GTDQLLAILSSSGTSGLPKAV------------T 215
                     |...|.....:|..||:...  .:..:..||.:|||:..||.|            .
Yeast   165 ---------IYRSLNNAKFVNTNPVKFPGFARSSDVALILHTSGTTSTPKTVPLLHLNIVRSTLN 220

  Fly   216 ISNSHQIIGSFLPVDSSIIQYNPNTLDWASGITMTINAAVFSLTSIIEDCDFDPANLCGLIEKYR 280
            |:|::::    .|:|.|   |....|....|:...:.:...:..|::....|.|........||.
Yeast   221 IANTYKL----TPLDRS---YVVMPLFHVHGLIGVLLSTFRTQGSVVVPDGFHPKLFWDQFVKYN 278

  Fly   281 ---------ISMVFVSSSQLAMLSNCPEFYAADLSSVKYFFYGGSNCSLEVQNKIRSRLSNEC-- 334
                     |||:.:         |.|:  ......:::.    .:||..:......:|..|.
Yeast   279 CNWFSCVPTISMIML---------NMPK--PNPFPHIRFI----RSCSSALAPATFHKLEKEFNA 328

  Fly   335 -VNFSYTLTELN--------SPGCLNFNFDEKPNSVGRPVRGIQIKIVNELGEAQGPNVVGEICF 390
             |..:|.:||.:        .||      ..||.:||:| :|:.:.|:::......|..|||:..
Yeast   329 PVLEAYAMTEASHQMTSNNLPPG------KRKPGTVGQP-QGVTVVILDDNDNVLPPGKVGEVSI 386

  Fly   391 NNGQKWPGYYKNPEETKK-MQDSENWFHTGDLGYMDEDGYLFIIDRLKDMLKYQTIMYYPSEIES 454
            .......||..||:..|: ....||:|.|||.||.|.:|:|.:..|:|:::........|.|::.
Yeast   387 RGENVTLGYANNPKANKENFTKRENYFRTGDQGYFDPEGFLVLTGRIKELINRGGEKISPIELDG 451

  Fly   455 VIAEMPNVVEACVFGIWDPVYGDKAAASVVKKQGTQLEAQDVVEYVRKRIPAKFKQLNGGALIVD 519
            ::...|.:.||..||:.|.:||....|::|.|:|.::..:::|.:::|.: |.|| :......||
Yeast   452 IMLSHPKIDEAVAFGVPDDMYGQVVQAAIVLKKGEKMTYEELVNFLKKHL-ASFK-IPTKVYFVD 514

  Fly   520 HIIQSGNRKANRAATKAEFLR 540
            .:.::...|..|......|.:
Yeast   515 KLPKTATGKIQRRVIAETFAK 535

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5568	NP_647992.1	CaiC	35..540	CDD:223395	104/474 (22%)
CG5568	NP_647992.1	Firefly_Luc_like	55..530	CDD:213279	102/464 (22%)
PCS60	NP_009781.3	FACL_fum10p_like	18..531	CDD:341249	103/470 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0318
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810