DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG5568 and DIP2B

DIOPT Version :9

Sequence 1:	NP_647992.1	Gene:	CG5568 / 38658	FlyBaseID:	FBgn0035641	Length:	545	Species:	Drosophila melanogaster
Sequence 2:	NP_775873.2	Gene:	DIP2B / 57609	HGNCID:	29284	Length:	1576	Species:	Homo sapiens

Alignment Length:	669	Identity:	121/669 - (18%)
Similarity:	214/669 - (31%)	Gaps:	236/669 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MGELQAGK---------------SPFKTRNTFDENLKIWSGGEKRSLFSPDLSIGEIIFQQMERN 50
            :|.|.|||               :....::.|...:..|     |:..:||    .::|..:...
Human   959 VGNLVAGKRIAQAAGRDLGQIEENDLVRKHQFLAEILQW-----RAQATPD----HVLFMLLNAK 1014

  Fly    51 AMLTAQISVTENTELTWKDIQTNAMKVASYMRKLG-LEQGDFVGVIGRLTTHLTALAYACFFNG- 113
            .......|..:        :...|.::||.:...| |..||.|.::......|.|..|.|.:.|
Human  1015 GTTVCTASCLQ--------LHKRAERIASVLGDKGHLNAGDNVVLLYPPGIELIAAFYGCLYAGC 1071

  Fly   114 -----TPYHALHTEYEQSAIERLFGITKPRLIFCDGDEFEKVQAATKGLQVQIVTMRNHPAGILR 173
                 .|.||.:.......:..:..::|...|.            |....::::..|...|.:
Human  1072 IPVTVRPPHAQNLTATLPTVRMIVDVSKAACIL------------TSQTLMRLLRSREAAAAV-- 1122

  Fly   174 IQDILTTPVEMNF-------RPVRLKDGTDQLLAILS-SSGTSGLPKAVTISNSHQIIGSFLPVD 230
              |:.|.|..::.       .|...|..|.::||.|. |..|:|:...|.:|:|
Human  1123 --DVKTWPTIIDTDDLPRKRLPQLYKPPTPEMLAYLDFSVSTTGMLTGVKMSHS----------- 1174

  Fly   231 SSIIQYNPNTLDWASGITMTINAAVFSLTSIIE-DCD----------FDPANLCGL--------- 275
                                   ||.:|...|: .|:          .||  .|||
Human  1175 -----------------------AVNALCRAIKLQCELYSSRQIAICLDP--YCGLGFALWCLCS 1214

  Fly   276 -------------------------IEKYRISMVFVSSSQLAM----LSNCPEFY---AADLSSV 308
                                     :.:|:|...|.|.|.:.:    |.|..|..   ..:||.|
Human  1215 VYSGHQSVLIPPMELENNLFLWLSTVNQYKIRDTFCSYSVMELCTKGLGNQVEVLKTRGINLSCV 1279

  Fly   309 KYFFYGGSNCSLEVQNKIRSRLSNECVNFSYTLTELN-SPGCLNFNFDEK--------------- 357
            :       .|.:..:.:.|..|..   :||....::. ||..::..|..:
Human  1280 R-------TCVVVAEERPRVALQQ---SFSKLFKDIGLSPRAVSTTFGSRVNVAICLQGTSGPDP 1334

  Fly   358 ----------------------PNSV-----GRPVRGIQIKIVNELGEAQGP---NVVGEICFNN 392
                                  |.|:     |:.:.|:::.|||.  |.:||   :.:|||..|:
Human  1335 TTVYVDLKSLRHDRVRLVERGAPQSLLLSESGKILPGVKVVIVNP--ETKGPVGDSHLGEIWVNS 1397

  Fly   393 GQKWPGYYKNPEETKKMQDSEN------------WFHTGDLGYM----------DEDGYLFIIDR 435
            .....|||...:......|..|            |..||.||::          :....|:::..
Human  1398 PHTASGYYTIYDSETLQADHFNTRLSFGDAAQTLWARTGYLGFVRRTELTAATGERHDALYVVGA 1462

  Fly   436 LKDMLKYQTIMYYPSEIESVIAEMPNVVEACVFGIWDPVYGDKAAASVVKKQGTQLEAQDVVEYV 500
            |.:.|:.:.:.|:|.:||:.::.:...:..|....|     ......||:..|::.||.|:|..|
Human  1463 LDETLELRGLRYHPIDIETSVSRIHRSIAECAVFTW-----TNLLVVVVELCGSEQEALDLVPLV 1522

  Fly   501 RKRIPAKFKQLNGGALIVD 519
            ...:..:...:.|..::||
Human  1523 TNVVLEEHYLIVGVVVVVD 1541

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5568	NP_647992.1	CaiC	35..540	CDD:223395	113/620 (18%)
CG5568	NP_647992.1	Firefly_Luc_like	55..530	CDD:213279	110/600 (18%)
DIP2B	NP_775873.2	DMAP_binding	14..131	CDD:283995
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	31..167
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	179..201
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	217..246
		CaiC	336..912	CDD:223395
		AFD_class_I	360..924	CDD:302604
		AMP-binding	995..1470	CDD:278902	98/555 (18%)
		AFD_class_I	1012..1565	CDD:302604	110/607 (18%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0318
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900