DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG5568 and CG6300

DIOPT Version :9

Sequence 1:	NP_647992.1	Gene:	CG5568 / 38658	FlyBaseID:	FBgn0035641	Length:	545	Species:	Drosophila melanogaster
Sequence 2:	NP_650828.1	Gene:	CG6300 / 42351	FlyBaseID:	FBgn0038730	Length:	537	Species:	Drosophila melanogaster

Alignment Length:	536	Identity:	289/536 - (53%)
Similarity:	393/536 - (73%)	Gaps:	0/536 - (0%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 PFKTRNTFDENLKIWSGGEKRSLFSPDLSIGEIIFQQMERNAMLTAQISVTENTELTWKDIQTNA 74
            |:...|::|.:.|||||......|.||||||||||.:|.|:..||||||.||.|.||..::..||
  Fly     2 PYTPENSYDNDQKIWSGEPVVKYFDPDLSIGEIIFHEMRRHPQLTAQISATEGTVLTRGELLANA 66

  Fly    75 MKVASYMRKLGLEQGDFVGVIGRLTTHLTALAYACFFNGTPYHALHTEYEQSAIERLFGITKPRL 139
            |::|||||.|||.|.|.||:|||.|||:.|:||||||||..:|:|:..|::..||:::.:|:|.:
  Fly    67 MRLASYMRSLGLLQSDIVGIIGRNTTHMLAVAYACFFNGIAFHSLNITYDRDTIEKIYKVTRPSI 131

  Fly   140 IFCDGDEFEKVQAATKGLQVQIVTMRNHPAGILRIQDILTTPVEMNFRPVRLKDGTDQLLAILSS 204
            |||||||||||::||..|.|:||||||||...::|.:::.||:|.||:|.:|:.|.||.||||.|
  Fly   132 IFCDGDEFEKVRSATAELDVKIVTMRNHPLDSIKIDEVVATPIEENFQPAKLEKGNDQTLAILCS 196

  Fly   205 SGTSGLPKAVTISNSHQIIGSFLPVDSSIIQYNPNTLDWASGITMTINAAVFSLTSIIEDCDFDP 269
            |||:|.||||||:||..|:.....:.::.:||:.|||||.:|:..||.:.|||.|.||.|..|||
  Fly   197 SGTTGTPKAVTITNSRHILAGNYHLTTADVQYSHNTLDWITGLLTTITSGVFSTTRIIADNAFDP 261

  Fly   270 ANLCGLIEKYRISMVFVSSSQLAMLSNCPEFYAADLSSVKYFFYGGSNCSLEVQNKIRSRLSNEC 334
            |....:||:|:::......|.:|::.|||:|...|:||::.:.:|||..:||||..||||||::|
  Fly   262 AFALRIIEEYKVTWTIQPPSSMALMINCPDFETCDMSSLRCYMFGGSRAALEVQKGIRSRLSHDC 326

  Fly   335 VNFSYTLTELNSPGCLNFNFDEKPNSVGRPVRGIQIKIVNELGEAQGPNVVGEICFNNGQKWPGY 399
            :.|.|..|||.:...:|.:||||..|||:.|.|:::||:|:.||:.||:.:||:|..|.|.|.||
  Fly   327 LQFVYGFTELGAMATINCHFDEKTGSVGQLVNGLKMKIINDDGESLGPDEIGEVCIMNNQHWSGY 391

  Fly   400 YKNPEETKKMQDSENWFHTGDLGYMDEDGYLFIIDRLKDMLKYQTIMYYPSEIESVIAEMPNVVE 464
            |.|..||:.|:||..|:|:|||||||.||:|:|:||.|:|||||.|||||::|||||:|||.|.|
  Fly   392 YGNEVETRNMRDSLGWYHSGDLGYMDRDGFLYIMDRKKEMLKYQNIMYYPNDIESVISEMPQVAE 456

  Fly   465 ACVFGIWDPVYGDKAAASVVKKQGTQLEAQDVVEYVRKRIPAKFKQLNGGALIVDHIIQSGNRKA 529
            .||||||..::||:|||:||||.|::|||||||:|||.|..:|:|||||||:|||.:.:|.|.|.
  Fly   457 VCVFGIWSNIFGDEAAAAVVKKLGSELEAQDVVDYVRSRTDSKYKQLNGGAVIVDDLQRSANGKT 521

  Fly   530 NRAATKAEFLRIMEKN 545
            ||.|.||.||.:..::
  Fly   522 NRMANKAYFLHLKNRS 537

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5568	NP_647992.1	CaiC	35..540	CDD:223395	279/504 (55%)
CG5568	NP_647992.1	Firefly_Luc_like	55..530	CDD:213279	259/474 (55%)
CG6300	NP_650828.1	CaiC	26..523	CDD:223395	273/496 (55%)
CG6300	NP_650828.1	AFD_class_I	47..522	CDD:302604	259/474 (55%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45471287
Domainoid	1	1.000	215	1.000	Domainoid score	I5876
eggNOG	1	0.900	-	-		E1_COG0318
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	290	1.000	Inparanoid score	I5187
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG26958
OrthoDB	1	1.010	-	-		D24284at7147
OrthoFinder	1	1.000	-	-		FOG0004528
OrthoInspector	1	1.000	-	-		mtm9651
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24096
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X778
	11	10.910