DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG5568 and CG4563

DIOPT Version :9

Sequence 1:	NP_647992.1	Gene:	CG5568 / 38658	FlyBaseID:	FBgn0035641	Length:	545	Species:	Drosophila melanogaster
Sequence 2:	NP_611913.1	Gene:	CG4563 / 37901	FlyBaseID:	FBgn0035006	Length:	537	Species:	Drosophila melanogaster

Alignment Length:	534	Identity:	183/534 - (34%)
Similarity:	297/534 - (55%)	Gaps:	11/534 - (2%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 KSPFKTRNTFDENLKIWSGGEKRSLFSPDLSIGEIIFQQMERNAMLTAQISVTENTELTWKDIQT 72
            |:.|.|  .|::..::|||..:.:::..:.|:|:|:|..:........||:..:.|.||..|:..
  Fly     4 KAVFPT--FFNKETQVWSGPPRPTVYDHNTSVGQIVFNSLRCWPTNVIQITDDDGTVLTNADMLA 66

  Fly    73 NAMKVASYMRKLGLEQGDFVGVIGRLTTHLTALAYACFFNGTPYHALHTEYEQSAIERLFGITKP 137
            .|.::|.:.:..||.|.|.||:|...:|.:..:|.||||..||:||::...|.:.::.|:.:|||
  Fly    67 YATRIALFFKSEGLTQEDRVGIIANSSTFVIPVATACFFQATPFHAVNYSREPAIVQGLYSVTKP 131

  Fly   138 RLIFCDGDEFEKVQAATKGLQVQIVTMRNHPAGILRIQDILTT-PVEMNFRPVRLKDGTDQLLAI 201
            :::|.||.::::::..||....:::|:.....|:..|:|::.. |.|..:.|..|..|.||:..:
  Fly   132 KIMFIDGPDYDRIKEITKEWSPKLITLTGKVEGVTSIEDLVKPHPAEKIYVPASLATGGDQIAVV 196

  Fly   202 LSSSGTSGLPKAVTISNSHQIIGSFLPVDSSIIQYNPNTLDWASGITMTINAAVFSLTSIIEDCD 266
            |.||||:||||||.:|:.|....:.|.:.:.:: |...|:||.:|.::|:.......|.||....
  Fly   197 LCSSGTAGLPKAVALSHRHIASTNSLCISTDVL-YTSATIDWMTGFSITVMNLTCGFTRIISRRT 260

  Fly   267 FDPANLCGLIEKYRISMVFVSSSQLAMLSNCPEFYAADLSSVKYFFYGGSNCSLEVQNKIRSRLS 331
            |.......|:.||:::.:.::..|...|...|...:..|.|:|..|..|...||.:..:.:..|.
  Fly   261 FSAETALYLVSKYKVTCLAMAPWQAYELFTSPLATSEQLESLKIAFVIGGWISLALLRRAQELLP 325

  Fly   332 NECVNFSYTLTELNSPGCLNFNFDEKPN-SVGRPVRGIQIKIVNELGEAQGPNVVGEICFNNGQK 395
            ...|.|||..||   .|.:..|.|.... ||||...|::|||..|.|:..|.|..||:..:.|.|
  Fly   326 KTYVMFSYGTTE---TGVVTINIDHSLECSVGRLAPGMRIKIQGEDGQQLGVNQTGEVLIDIGLK 387

  Fly   396 WPGYYKNPEET-KKMQDSENWFHTGDLGYMDEDGYLFIIDRLKDMLKYQTIMYYPSEIESVIAEM 459
            |.||..|||:| ..:||  .|.:.|||||.|||..|:::||.||:|||::..|:|:|||.:|||:
  Fly   388 WEGYLSNPEDTATTLQD--GWINLGDLGYFDEDNNLYLVDRKKDLLKYKSKHYWPNEIEQIIAEL 450

  Fly   460 PNVVEACVFGIWDPVYGDKAAASVVKKQGTQLEAQDVVEYVRKRIPAKFKQLNGGALIVDHIIQS 524
            |.|...||.|:.|..|||.|.|.::||:|.::..|.|:::|.:|:...:||||.|.:.||...::
  Fly   451 PEVEHVCVVGVRDARYGDAAGALIIKKEGAEIADQKVIDHVAQRVVVDYKQLNAGVIFVDKFPKN 515

  Fly   525 GNRKANRAATKAEF 538
            .|.|..|:..:..|
  Fly   516 ANGKVMRSLAREVF 529

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5568	NP_647992.1	CaiC	35..540	CDD:223395	176/507 (35%)
CG5568	NP_647992.1	Firefly_Luc_like	55..530	CDD:213279	170/477 (36%)
CG4563	NP_611913.1	CaiC	21..531	CDD:223395	176/515 (34%)
CG4563	NP_611913.1	Firefly_Luc_like	49..521	CDD:213279	170/477 (36%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45471306
Domainoid	1	1.000	215	1.000	Domainoid score	I5876
eggNOG	1	0.900	-	-		E1_COG0318
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG26958
OrthoDB	1	1.010	-	-		D24284at7147
OrthoFinder	1	1.000	-	-		FOG0004528
OrthoInspector	1	1.000	-	-		mtm9651
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24096
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X778
	10	9.860