DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG5568 and CG9993

DIOPT Version :9

Sequence 1:	NP_647992.1	Gene:	CG5568 / 38658	FlyBaseID:	FBgn0035641	Length:	545	Species:	Drosophila melanogaster
Sequence 2:	NP_611518.1	Gene:	CG9993 / 37358	FlyBaseID:	FBgn0034553	Length:	543	Species:	Drosophila melanogaster

Alignment Length:	543	Identity:	162/543 - (29%)
Similarity:	260/543 - (47%)	Gaps:	47/543 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly    17 FDENLKIWSGGEKRSLFSPDLSIGEIIFQQMERNAMLTAQISVTENTELTWKDIQTNAMKVASYM 81
            :|...|||||.:.:..:.||:::||:....:...:....|:......|||...:...:.::|...
  Fly     6 YDSFEKIWSGPKDKEYYGPDMTLGEVALIILRLYSDKVMQVYDPTGEELTGSQLLEQSRRLAHAF 70

  Fly    82 RKLGLEQGDFVGVIGRLTTHLTALAYACFFNGTPYHALHTEYEQSAIERLFGITKPRLIFCDGDE 146
            ::|.|::||.||:..:.||:||.:..|...||||.:.||.:::......:|.||||::||||.|.
  Fly    71 QRLKLQRGDVVGISAKNTTYLTEVVIAALLNGTPINPLHPDFDAETTAYMFEITKPKVIFCDLDN 135

  Fly   147 FEKVQAATKGL--QVQIVTMRNHPAGILRIQDILTTPVEMNFRPVRLKDGT-------------- 195
            ::.:.|....|  :.:|:.:.....|:..|||:|.             ||.
  Fly   136 YQTLSAVKSSLKFKTEIILLTGTLPGVRNIQDLLA-------------DGCTGYDEKTLFACPHL 187

  Fly   196 --DQLLAILSSSGTSGLPKAVTISNSHQIIGSFLP----VDSSIIQYNPNTLDWASGITMTINAA 254
              |....|::|||.:||||.||.|:...:..:.:|    .|:.:..::|  |.|.|.|...:.:.
  Fly   188 CGDDTAFIITSSGVTGLPKGVTRSHRSLLNSAKIPQLFTSDTVLFCFSP--LYWISCIFTLLASL 250

  Fly   255 VFSLTSIIEDCDFDPANLCGLIEKYRISMVFVSSSQLAMLSNCPE--FYAADLSSVKYFFYGGSN 317
            |.....||.:..|..|....|:|::::|.|......:|:|:..||  ..||.:..|:.|...||.
  Fly   251 VNGCRRIITNRPFSVAYFADLVERHQVSFVLTVPHHMALLAKSPERQELAAKMQCVQSFVCSGSK 315

  Fly   318 CSLEVQNKIRSRLSNECVNFSYTLTELNSPGCLNFNFDEKPNSVGRPVRGIQIKIVNELGEAQGP 382
            ..:.:..::...|........|.|||   .|.::.|......|.||.:|.:|:::|:..|::.||
  Fly   316 VPMGIWRQLYELLGANRFAVLYGLTE---TGGISKNVGGPLGSEGRLLRNVQVRVVDPHGQSLGP 377

  Fly   383 NVVGEICFNNGQKWPGYYKNPEETK-KMQDSENWFHTGDLGYMDEDGYLFIIDRLKDMLKYQTIM 446
            |..|:|......:|.|||.||:||: .:.....|..|||.||.|::|.|....|..|:.||....
  Fly   378 NQTGQILVRLNLRWGGYYHNPQETQVTVTPDGKWLLTGDHGYFDDEGCLHFQSRDTDVFKYNHFP 442

  Fly   447 YYPSEIESVIAEMPNVVEACVFGIWDPVYGDKAAASVVKKQ---GTQLEAQDVVEYVRKRIPAKF 508
            .||.:||.||..:|.|.|..||||.|.|..:..|.:||:.:   |.||...||...|.:.:...|
  Fly   443 IYPKQIEDVILHLPGVHEVAVFGIPDEVSTNLTACAVVRNEDELGAQLTEADVKGVVAQHLSDAF 507

  Fly   509 KQLNGGALIVDHIIQSGNRKANR 531
             .:.||...||::.::.|.|..|
  Fly   508 -HIRGGVFFVDNLPKTQNSKVQR 529

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5568	NP_647992.1	CaiC	35..540	CDD:223395	156/525 (30%)
CG5568	NP_647992.1	Firefly_Luc_like	55..530	CDD:213279	151/502 (30%)
CG9993	NP_611518.1	CaiC	21..532	CDD:223395	156/528 (30%)
CG9993	NP_611518.1	AFD_class_I	45..528	CDD:302604	151/501 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45471330
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0318
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG26958
OrthoDB	1	1.010	-	-		D24284at7147
OrthoFinder	1	1.000	-	-		FOG0004528
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24096
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X778
	8	7.860