DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG5568 and Acsm5

DIOPT Version :9

Sequence 1:	NP_647992.1	Gene:	CG5568 / 38658	FlyBaseID:	FBgn0035641	Length:	545	Species:	Drosophila melanogaster
Sequence 2:	XP_006507967.1	Gene:	Acsm5 / 272428	MGIID:	2444086	Length:	591	Species:	Mus musculus

Alignment Length:	560	Identity:	126/560 - (22%)
Similarity:	222/560 - (39%)	Gaps:	107/560 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 LQAGKSPFKTRNTFDEN-LKIWSGGEKRSLFSPDLSIGEIIFQQMERNAMLTAQISVTENTELTW 67
            :..|:.|......|..: |.:||..||.....|:.:...:       |.         ..||:.|
Mouse    54 ISLGRQPVPEYFNFAHDVLDVWSQLEKTGHRPPNPAFWWV-------NG---------SGTEVKW 102

  Fly    68 --KDIQTNAMKVASYMRKL-GLEQGDFVGVIGRLTTHLTALAYACFFNG-------TPYHALHTE 122
              :::...:.|.|:.:..: ||:.||.:.::.........::.||...|       :...|...:
Mouse   103 TFEELGKQSRKAANVLEGVCGLQPGDRMMLVLPRLPDWWLISVACMRTGVVMIPGVSQLTAKDLK 167

  Fly   123 YEQSAIERLFGITKPRLIFCDGDEFEKVQAATKGLQVQIVTMRNHPAGILRIQDIL--TTPVEMN 185
            |...|......:|...|    ..:.:.:.|....||.:::.......|.:..:::|  .:| |.|
Mouse   168 YRLQAARAKSIVTSDAL----APQVDAISADCPSLQTKLLVSDTSRPGWINFRELLRAASP-EHN 227

  Fly   186 FRPVRLKDGTDQLLAILSSSGTSGLPKAVTISNSHQIIG------SFLPVDSSIIQYNPNTLD-- 242
            .  ||.:.|..  :||..:|||:|.||.|..|.|...:|      .::.:..|.|.:  ||.|
Mouse   228 C--VRTRSGDS--VAIYFTSGTTGAPKMVEHSQSSYGLGFVASGRRWMALTESDIFW--NTTDTG 286

  Fly   243 -----------WASGITMTIN--AAVFSLTSIIEDCDFDPANLCGLIEKYRISMVFVSSSQLAML 294
                       |::|..:.::  ..|.:.|.:...|.|....||.:...:|:   .|........
Mouse   287 WVKAAWTLFSAWSNGACIFVHELPRVDAKTILNTLCRFPITTLCCVPTLFRL---LVQEDLTRYK 348

  Fly   295 SNCPEFYAADLSSVKYFFYGGSNCSLEVQNKIRSRLSNECVNFSYTLTEL-----NSPGCLNFNF 354
            ..|          :::...||...:.:|::|.:|:...| ::..|..:|.     ||.     |.
Mouse   349 FQC----------LRHCLTGGEALNPDVRDKWKSQTGLE-LHEGYGQSETVVICGNSR-----NS 397

  Fly   355 DEKPNSVGRPVRGIQIKIVNELGEAQGPNVVGEI----------CFNNGQKWPGYYKNPEETKKM 409
            ..|..|:|:......::||:|.|....|...|.|          ||.|     .|..|||:|...
Mouse   398 TIKSGSMGKASPPYDVQIVDEEGNVLPPGKEGNIAVRIKPTRPFCFFN-----CYLDNPEKTAAS 457

  Fly   410 QDSENWFHTGDLGYMDEDGYLFIIDRLKDMLKYQTIMYYPSEIESVIAEMPNVVEACVFGIWDPV 474
            :..: ::.|||..:||||||.:.:.|..|::...:....|.|:||.:||.|.|:|:.|....||:
Mouse   458 EQGD-FYITGDRAHMDEDGYFWFLGRNDDVINSSSYRIGPVEVESALAEHPAVLESAVVSSPDPI 521

  Fly   475 YGDKAAASVV-----KKQGTQLEAQDVVEYVRKRIPAKFK 509
            .|:...|.:|     .....:...:::.|:| |.:.|.:|
Mouse   522 RGEVVKAFIVLSPAYASHDPEALTRELQEHV-KTVTAPYK 560

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5568	NP_647992.1	CaiC	35..540	CDD:223395	118/528 (22%)
CG5568	NP_647992.1	Firefly_Luc_like	55..530	CDD:213279	116/508 (23%)
Acsm5	XP_006507967.1	AFD_class_I	61..589	CDD:388389	124/553 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D683933at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	2.010