DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG5568 and acs-14

DIOPT Version :9

Sequence 1:	NP_647992.1	Gene:	CG5568 / 38658	FlyBaseID:	FBgn0035641	Length:	545	Species:	Drosophila melanogaster
Sequence 2:	NP_505451.1	Gene:	acs-14 / 179330	WormBaseID:	WBGene00008669	Length:	544	Species:	Caenorhabditis elegans

Alignment Length:	514	Identity:	145/514 - (28%)
Similarity:	248/514 - (48%)	Gaps:	62/514 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    65 LTWKDIQTNAMKVASYMRKLGLEQGDFVGVIGRLTTHLTALAYACFFNG---TPYHALHTEYEQS 126
            :|::.::.:|..||.|:..:|.:: |...|:.....|.|:....|..||   :...||.|:||
Worm    48 ITFEQLRKDAFAVAMYLHSIGFKK-DVAAVVLPNVWHYTSFFIGCAINGGAVSGASALFTDYE-- 109

  Fly   127 AIERLFGITKPRLIFCDGDEFEKVQAATK---GLQVQIVTMR----NHPAGILRIQDILTTPV-E 183
             ::|.|..::.:::|...|...||..|.|   .:|..||..:    :.|||::...::::||| .
Worm   110 -LQRQFVDSRAKVVFTYEDFLPKVLLAVKQSPNIQKIIVIPKPVGSSLPAGVVSWNEVVSTPVTA 173

  Fly   184 MNFRPVRLKDGTDQLLAILSSSGTSGLPKAVTIS--NSHQIIGSFLPVDSSIIQ---------YN 237
            :...|:   |..:.||.:..||||:|.||.|.:|  |...:|..:|.:|.|.|.         ||
Worm   174 LPQVPI---DVHNDLLVLPYSSGTTGPPKGVMLSHYNFTSMISMYLAIDKSHILDVLDPNWDCYN 235

  Fly   238 PNTLDW-----ASGITMTINAAVFSLTSIIEDCDFDPANLCGLIEKYRIS--------MVFVSSS 289
            ...|.:     ..|..:..:..:..:|.|:.. .|:|.|....::.|::.        |||::..
Worm   236 EKALLFLPFYHVYGFGLLNHCLLKGMTGIVMS-HFEPNNFLTAVQNYKVRCLCLVPPIMVFLAKH 299

  Fly   290 QLAMLSNCPEFYAADLSSVKYFFYGGSNCSLEVQNKIRSRLSN-ECVNFSYTLTELNSPGCL-NF 352
            .:     |.:|   |||||:....|.:....::..:::.:.:| :.:...|.:||.:....| :.
Worm   300 PI-----CDKF---DLSSVQMIMAGAAPAGKDLIEELKRKYTNLKYIQQGYGMTECSMASHLPDL 356

  Fly   353 NFDEKPNSVGRPVRGIQIKIVNELGEAQGP-NVVGEICFNNGQKWPGYYKNPEETKKMQDSENWF 416
            ..|:...|||:....:.:|||....:.:.| |..||||........||...||.|.... .:.|.
Worm   357 RNDQPYGSVGKLASNLVMKIVEPGTDREQPVNQRGEICVRGPTIMLGYLGRPEATASTV-IDGWL 420

  Fly   417 HTGDLGYMDEDGYLFIIDRLKDMLKYQTIMYYPSEIESVIAEMPNVVEACVFGIWDPVYGDKAAA 481
            ||||:||::|||.|||:||||:::|.:.:...|:|:|.::...|.:.:..|.||.|...|:...|
Worm   421 HTGDIGYLNEDGNLFIVDRLKELIKVKGLQVPPAELEDLLLSHPKIRDCAVIGIPDAKAGELPKA 485

  Fly   482 SVVKKQGTQLEAQDVVEYVRKRIPAKFKQLNGGALIVDHIIQSGNRKANRAATKAEFLR 540
            .||:...| |..|:|.::|:.:: :.:|||.||...::.|.:|...|..|     .|||
Worm   486 FVVRADNT-LTEQEVKDFVKPKV-SPYKQLEGGVEFIEEIPKSAAGKILR-----RFLR 537

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5568	NP_647992.1	CaiC	35..540	CDD:223395	143/512 (28%)
CG5568	NP_647992.1	Firefly_Luc_like	55..530	CDD:213279	141/502 (28%)
acs-14	NP_505451.1	CaiC	12..539	CDD:223395	145/514 (28%)
acs-14	NP_505451.1	Firefly_Luc_like	37..532	CDD:213279	141/502 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0318
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D683933at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24096
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	5.920