DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG5568 and acs-1

DIOPT Version :9

Sequence 1:	NP_647992.1	Gene:	CG5568 / 38658	FlyBaseID:	FBgn0035641	Length:	545	Species:	Drosophila melanogaster
Sequence 2:	NP_001023937.1	Gene:	acs-1 / 179043	WormBaseID:	WBGene00018488	Length:	623	Species:	Caenorhabditis elegans

Alignment Length:	496	Identity:	114/496 - (22%)
Similarity:	207/496 - (41%)	Gaps:	55/496 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    61 ENTELTWKDIQTNAMKVASYMRKLGLEQGDFVGVIGRLTTHLTALAYACFFNGTPYHALHTEYEQ 125
            |....|:..:.|:|..:|..:..|||::||.:|:.|..|...|...:|....|.....::..|:.
Worm    90 EGIRKTYSQVATDAENLACGLLHLGLKKGDRIGIWGPNTYEWTTTQFASALAGMVLVNINPSYQS 154

  Fly   126 S----AIERLFGITKPRLIFCDGDEFEKVQAATKGLQVQI---------VTMRN----------- 166
            .    |||:: ||.  .||...|.:......:.|.:..::         :|.||
Worm   155 EELRYAIEKV-GIR--ALITPPGFKKSNYYQSIKDILPEVTLKEPGKSGITSRNFTCFQHLIMFD 216

  Fly   167 -----HPAGILRIQDILTTPVE---MNFRPVRLKDGTDQLLAILSSSGTSGLPKAVTISNSHQII 223
                 :| |..:..|::....|   .:...:..:...|..|.|..:|||:|.||..|::: |.::
Worm   217 EEDKIYP-GAWKYTDVMKMGTEEDRHHLSKIERETQPDDSLNIQYTSGTTGQPKGATLTH-HNVL 279

  Fly   224 GSFLPV-------DSSIIQYNPNTLDWASGITMTINAAVFSL-TSIIEDCDFDPANLCGLIEKYR 280
            .:...|       :...|...||.|....|..|.:.||:..| |.:.....||.......|.:.:
Worm   280 NNAFFVGLRAGYSEKKTIICIPNPLYHCFGCVMGVLAALTHLQTCVFPAPSFDALAALQAIHEEK 344

  Fly   281 ISMVFVSSSQLAMLSNCPEFYAADLSSVKYFFYGGSNCSLEVQNKIRSRLSNECVNFSYTLTELN 345
            .:.::.:.:....:.|.||:...:..|::..|..|:.|.:.:..::...:....:...|..|| .
Worm   345 CTALYGTPTMFIDMINHPEYANYNYDSIRSGFIAGAPCPITLCRRLVQDMHMTDMQVCYGTTE-T 408

  Fly   346 SPGCLNFNFDEKP----NSVGRPVRGIQIKIVNELGEAQGPNVVGEICFNNGQKWPGYYKNPEET 406
            ||.......|:.|    .|||..:..::..||::........|.||:..........|:.:.|:|
Worm   409 SPVSFMSTRDDPPEQRIKSVGHIMDHLEAAIVDKRNCIVPRGVKGEVIVRGYSVMRCYWNSEEQT 473

  Fly   407 KKMQDSENWFHTGDLGYMDEDGYLFIIDRLKDMLKYQTIMYYPSEIESVIAEMPNVVEACVFGIW 471
            ||....:.|:||||:..|.::|.:.|:.|.|||:.......||:|:|..:.:..:|.:..:.|:.
Worm   474 KKEITQDRWYHTGDIAVMHDNGTISIVGRSKDMIVRGGENIYPTEVEQFLFKHQSVEDVHIVGVP 538

  Fly   472 DPVYGDKAAASV---VKKQGTQLEAQDVVEYVRKRIPAKFK 509
            |..:|:...|.|   ...:|...| :|:..:.:.:| |.||
Worm   539 DERFGEVVCAWVRLHESAEGKTTE-EDIKAWCKGKI-AHFK 577

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5568	NP_647992.1	CaiC	35..540	CDD:223395	114/496 (23%)
CG5568	NP_647992.1	Firefly_Luc_like	55..530	CDD:213279	114/496 (23%)
acs-1	NP_001023937.1	PRK08315	53..615	CDD:236236	114/496 (23%)
acs-1	NP_001023937.1	FACL_like_2	252..604	CDD:213284	81/330 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910