DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG5568 and acs-6

DIOPT Version :9

Sequence 1:	NP_647992.1	Gene:	CG5568 / 38658	FlyBaseID:	FBgn0035641	Length:	545	Species:	Drosophila melanogaster
Sequence 2:	NP_495450.1	Gene:	acs-6 / 174156	WormBaseID:	WBGene00022849	Length:	565	Species:	Caenorhabditis elegans

Alignment Length:	552	Identity:	128/552 - (23%)
Similarity:	236/552 - (42%)	Gaps:	78/552 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    38 SIGEIIFQ------QMERNAMLTAQISVTENTELTWKDIQTNAMKVASYMRKLGLEQGDFVG-VI 95
            ::.|.||:      ...::|:.......|...:| :||::.....:|:.:.|||.:.||... ..
Worm    16 TVHERIFEACRIHASANKDAVCFIDAETTTKKKL-YKDVEPTVNSLATALVKLGFKPGDVASQAF 79

  Fly    96 GRLTTHLTALAYACFFNGTPYH--ALHTEYEQSAIERLFGITKPRLIFCDGDEFEKVQAAT---K 155
            ......|.|:.......|...:  |:.|:||   ::..|..:...::|.|.|...:::.||   .
Worm    80 PNCPEFLVAMLAVMKCGGAMSNASAIFTDYE---LQLQFCDSNTSIVFTDEDRLARIRRATAKCP 141

  Fly   156 GLQVQIVTMR------NHPAGILRIQDILTTPVEMNFRPVRLKDGTDQLLAILSSSGTSGLPKAV 214
            |:: :|:.:|      ..|..:|...::..||.:    |:.:....|.:..:..||||:|.||..
Worm   142 GVR-KIICLRTFPLRTEFPENVLDYVELTQTPDQ----PINVNVSMDSIALLPYSSGTTGRPKGC 201

  Fly   215 TISNSHQIIGSFLPVDSSIIQ---------------YNPNT---LDW--ASGITMTINAAVFSLT 259
            .:  :|:.||:.|.|..:.::               :..:|   |.|  |.|:.......:..:|
Worm   202 QL--THRNIGAMLDVAKAHLETDVAPAMFGKEKATWHKEHTVLLLPWYHAYGLNTMFETILLGMT 264

  Fly   260 SIIEDCDFDPANLCGLIEKYRISMVFVSSSQLAMLSN---CPEFYAADLSSVKYFFYGGSNCSLE 321
            .|:.. .||...:...|:.|::.:.::....|..|:.   .|.|..|..  :|.....|:....:
Worm   265 GIVFK-KFDTIVMLNRIKFYKVKLAWLVPPMLIFLAKDPMVPIFNTAPF--LKVIMSAGATAGKQ 326

  Fly   322 VQNKIRSRLSNECVNFSYTLTELNSPGCLNFNFDEKP--------NSVGRPVRGIQIKIVN-ELG 377
            :..::..|..|..:..:|.:||:       ..|...|        .:||......::||:: |..
Worm   327 LCEEVSKRFPNAWLCQAYGMTEM-------VQFTTIPRFEDGNCFETVGNLASTYELKILDKEKK 384

  Fly   378 EAQGPNVVGEICFNNGQKWPGYYKNPEETKKMQDSENWFHTGDLGYMDEDGYLFIIDRLKDMLKY 442
            |....|.||::||.......||.|  .|...:.|.:.:..|||||.:|:.|.:.:..|:|:::|.
Worm   385 EITTINTVGQLCFRGPTVMKGYLK--REEADIIDKDGFLLTGDLGSIDDKGRIHVTGRIKELIKV 447

  Fly   443 QTIMYYPSEIESVIAEMPNVVEACVFGIWDPVYGDKAAASVVKKQGTQLEAQDVVEYVRKRIPAK 507
            ..:...|.|||.|:...|.|.:..|.|:.|...|:...|.:|||..|..|| ::.|:||::: :.
Worm   448 NGMQVPPVEIEDVLLLHPKVKDCAVIGVPDEHKGESPKAYIVKKDHTLTEA-ELTEFVRQKL-SS 510

  Fly   508 FKQLNGGALIVDHI--IQSGNRKANRAATKAE 537
            :|.::....| |.|  :.||..:..:....||
Worm   511 YKWIDTYEFI-DSIPKLPSGKIQRKKLKKMAE 541

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5568	NP_647992.1	CaiC	35..540	CDD:223395	128/552 (23%)
CG5568	NP_647992.1	Firefly_Luc_like	55..530	CDD:213279	122/520 (23%)
acs-6	NP_495450.1	CaiC	15..541	CDD:223395	126/550 (23%)
acs-6	NP_495450.1	Firefly_Luc_like	37..532	CDD:213279	122/520 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160160501
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0318
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24096
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.840