DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG5568 and ACSM1

DIOPT Version :9

Sequence 1:	NP_647992.1	Gene:	CG5568 / 38658	FlyBaseID:	FBgn0035641	Length:	545	Species:	Drosophila melanogaster
Sequence 2:	NP_001305819.1	Gene:	ACSM1 / 116285	HGNCID:	18049	Length:	577	Species:	Homo sapiens

Alignment Length:	491	Identity:	102/491 - (20%)
Similarity:	195/491 - (39%)	Gaps:	67/491 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    61 ENTELTW--KDIQTNAMKVAS-YMRKLGLEQGDFVGVIGRLTTHLTALAYACFFNGTPYHALHTE 122
            :..|:.|  :::.....:||: :.:..||:|||.:.::.........:|..|...|..:......
Human    80 QGDEVKWSFREMGDLTRRVANVFTQTCGLQQGDHLALMLPRVPEWWLVAVGCMRTGIIFIPATIL 144

  Fly   123 YEQSAIERLFGITKPR-LIFCD--GDEFEKVQAATKGLQVQIVTMRNHPAGILRIQDILTTPVEM 184
            .:...|.....::|.: ::..|  ..|.:.:.:....|:.:::...:...|.|..:.::.:....
Human   145 LKAKDILYRLQLSKAKGIVTIDALASEVDSIASQCPSLKTKLLVSDHSREGWLDFRSLVKSASPE 209

  Fly   185 NFRPVRLKDGTDQLLAILSSSGTSGLPKAVTISNSHQIIGSFLPVDSSIIQYNPNTLDWASGITM 249
            :   ..:|..|...:.|..:|||:|.||....|:...:..|| |....:.....:.:.|....:.
Human   210 H---TCVKSKTLDPMVIFFTSGTTGFPKMAKHSHGLALQPSF-PGSRKLRSLKTSDVSWCLSDSG 270

  Fly   250 TINAAVFSL--------TSIIEDC-DFDPANLCGLIEKYRISMVFVSSSQLAMLSNCPEFYAADL 305
            .|.|.:::|        |..|... .||...:...:.||.|:..:..||...|:      ...|.
Human   271 WIVATIWTLVEPWTAGCTVFIHHLPQFDTKVIIQTLLKYPINHFWGVSSIYRMI------LQQDF 329

  Fly   306 SSVKY----FFYGGSNCSLEVQNKIRSRLSNECVNFSYTLTELNSPGCLNFNFDEKPNSVGRPVR 366
            :|:::    ..|.|....|....:...|.:...:..:|..:|........:....||..:|:...
Human   330 TSIRFPALEHCYTGGEVVLPKDQEEWKRRTGLLLYENYGQSETGLICATYWGMKIKPGFMGKATP 394

  Fly   367 GIQIKIVNELGEAQGPNVVGEI--------------CFNNGQKWPGYYKNPEETKKMQDSENWFH 417
            ...::::::.|....||..|.|              |         |..:||:|.|::..: :::
Human   395 PYDVQVIDDKGSILPPNTEGNIGIRIKPVRPVSLFMC---------YEGDPEKTAKVECGD-FYN 449

  Fly   418 TGDLGYMDEDGYLFIIDRLKDMLKYQTIMYYPSEIESVIAEMPNVVEACVFGIWDPVYGDKAAAS 482
            |||.|.|||:||:..:.|..|::........|:|:||.:.|.|.|.|:.|.|..||:.|:...|.
Human   450 TGDRGKMDEEGYICFLGRSDDIINASGYRIGPAEVESALVEHPAVAESAVVGSPDPIRGEVVKAF 514

  Fly   483 VV---------KKQGTQLEAQDVVEYVRKRIPAKFK 509
            :|         |.|.|:...|.|     |.:.|.:|
Human   515 IVLTPQFLSHDKDQLTKELQQHV-----KSVTAPYK 545

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5568	NP_647992.1	CaiC	35..540	CDD:223395	102/491 (21%)
CG5568	NP_647992.1	Firefly_Luc_like	55..530	CDD:213279	102/491 (21%)
ACSM1	NP_001305819.1	MACS_euk	45..574	CDD:341251	102/491 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D683933at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.920