DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment vn and Celsr3

DIOPT Version :9

Sequence 1:	NP_523942.2	Gene:	vn / 38657	FlyBaseID:	FBgn0003984	Length:	623	Species:	Drosophila melanogaster
Sequence 2:	NP_112610.1	Gene:	Celsr3 / 83466	RGDID:	621787	Length:	3313	Species:	Rattus norvegicus

Alignment Length:	505	Identity:	92/505 - (18%)
Similarity:	164/505 - (32%)	Gaps:	153/505 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly   174 NLLYNGMPSEAAS---SKMRRHI-QPSQLPHQPESRAQLPSNYSSRPAVRSYLIESY-------- 226
            :|....:|.:|.|   |.:|... .||:|..||:|...:....:.|.::|. .:|::
  Rat   142 HLRRGSLPLDALSPGDSDLRNSSPHPSELLAQPDSPRPVAFQRNGRRSIRK-RVETFRCCGKLWE 205

  Fly   227 -------EMPESMLEDRSP----------------EQAARSRRDGSNTNGSRQQQRTGHRQQLQQ 268
                   |...:...||.|                :.|.|:.|.......:..:.||...:...:
  Rat   206 PGHKGQGERSATSTVDRGPLRRDCLPGSLGSGLGEDSAPRAVRTAPAPGSAPHESRTAPERMRSR 270

  Fly   269 D--KRDHRRQRQD----------QQKEQRQQQQQRQHKSGNKHQQQQQQRRKHQRKHQRYNRYCS 321
            .  :|....:|..          :.|......|.|..::.|:|.|..|           || |.:
  Rat   271 GLFRRGFLFERPGPRPPGFPTGAEAKRILSTNQARSRRAANRHPQFPQ-----------YN-YQT 323

  Fly   322 ----------------ARDP-----AQLAFAAPTVF-------------QGVFKSMSA-DRRVNF 351
                            |:||     .:|.::...:.             .|:.::.:| ||.
  Rat   324 LVPENEAAGTAVLRVVAQDPDPGEAGRLVYSLAALMNSRSLELFSIDPQSGLIRTAAALDRE--- 385

  Fly   352 SATMKVEKVYKQQHD---LQLPTLVRLQFALSNSSG---ECDIYRERLMPRGMLRSGNDLQQASD 410
            |......:|..|.|.   |...|:|.:..|..|...   |...|||.|.        .::::...
  Rat   386 SMERHYLRVTAQDHGSPRLSATTMVAVTVADRNDHAPVFEQAQYRETLR--------ENVEEGYP 442

  Fly   411 ISYMMFVQQTNPGN----FTILGQPMRVTHLVVEAVETAVSENYTQNAEVTKIFSKPSKAIIKHG 471
            |..:.......|.|    :..:|.|         |..||.:..:..:.. :.:.|...:...:|.
  Rat   443 ILQLRATDGDAPPNANLRYRFVGSP---------AARTAAAAAFEIDPR-SGLISTSGRVDREHM 497

  Fly   472 KKLRIVCEVSGQ---PPPKVTWFK------DEK----SINRKRNIYQFKHHKRRSELIVRSFNSS 523
            :...:|.|.|.|   |.|:....:      ||.    ..:.||.:.|.:...|...:::|.  ::
  Rat   498 ESYELVVEASDQGQEPGPRSATVRVHITVLDENDNAPQFSEKRYVAQVREDVRPHTVVLRV--TA 560

  Fly   524 SDAGRYECRAKNKASKAIAKRRIMIKASPVHFPTDRSASGI----PCNFD 569
            :|        |:|.:..:....|:...|..||..|.....|    |.:|:
  Rat   561 TD--------KDKDANGLVHYNIISGNSRGHFAIDSLTGEIQVMAPLDFE 602

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
vn	NP_523942.2	IGc2	471..538	CDD:197706	16/79 (20%)
vn	NP_523942.2	EGF	566..598	CDD:278437	1/4 (25%)
Celsr3	NP_112610.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	148..187		11/38 (29%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	205..269		9/63 (14%)
		Cadherin_repeat	321..420	CDD:206637	18/101 (18%)
		Cadherin_repeat	428..532	CDD:206637	22/121 (18%)
		Cadherin_repeat	541..638	CDD:206637	14/72 (19%)
		Cadherin_repeat	646..743	CDD:206637
		Cadherin_repeat	751..845	CDD:206637
		Cadherin_repeat	853..948	CDD:206637
		Cadherin_repeat	956..1054	CDD:206637
		Cadherin_repeat	1062..1156	CDD:206637
		Cadherin_repeat	1176..1257	CDD:206637
		EGF_CA	1428..1462	CDD:238011
		EGF_CA	1472..1505	CDD:238011
		LamG	1508..1691	CDD:238058
		EGF_CA	1717..1748	CDD:238011
		LamG	1755..1911	CDD:238058
		EGF_CA	1939..1973	CDD:238011
		EGF_CA	1973..2011	CDD:238011
		Laminin_EGF	<1994..2033	CDD:278482
		EGF_Lam	2030..>2054	CDD:238012
		EGF_Lam	2067..>2105	CDD:238012
		HormR	2117..2181	CDD:214468
		GAIN	2201..2446	CDD:293098
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	2356..2395
		GPS	2474..2527	CDD:197639
		7tm_2	2534..2766	CDD:278432
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	2887..2927
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	2977..3004
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	3091..3242
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	3255..3313
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910