DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment vn and nrg1

DIOPT Version :9

Sequence 1:	NP_523942.2	Gene:	vn / 38657	FlyBaseID:	FBgn0003984	Length:	623	Species:	Drosophila melanogaster
Sequence 2:	NP_001264015.1	Gene:	nrg1 / 796461	ZFINID:	ZDB-GENE-050302-113	Length:	730	Species:	Danio rerio

Alignment Length:	301	Identity:	75/301 - (24%)
Similarity:	134/301 - (44%)	Gaps:	56/301 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly   327 QLAFAAPTVFQGVFKS------------MSADRRVNFSATMKVEKVYKQQHDLQLPTLVRLQFAL 379
            :||..:..||:|..:.            |:|.|:|.    ::|::|::.:
Zfish    46 ELARRSGVVFEGKLQEEERAERNWTETPMNASRQVR----VRVQQVWQLK--------------- 91

  Fly   380 SNSSGECDIYRERLMPRGMLRSGNDLQQASDISYMMFVQQTNPGN-FTILGQPMRVTHLVVEAVE 443
              :.|   :.::.::.......|...|..:.|.||.|::.||..: ||.:..|:...    ..|.
Zfish    92 --AGG---LIKDSVVSLVWFEGGRCFQLNTGIRYMFFIEPTNDTSVFTAVFPPVETK----RTVR 147

  Fly   444 TAVSENYTQNAEVTKIFSKPSKAIIKHGKKLRIVCEV-SGQPPPKVTWFKDEKSINRKRNIYQFK 507
            ..||:...|:....|:.:..| ..::.|||..:.||: :|.|.|.|.|:|:.|.:..|......|
Zfish   148 KDVSQVLCQDCAEPKLKNLRS-VTVEDGKKTVLKCEILAGNPAPNVKWYKNGKELTGKNKPKSIK 211

  Fly   508 HHKRR----SELIVRSFNSSSDAGRYECRAKNKASKAIAKRRI-MIKASPVHFPTDRSASGI-PC 566
            ..|::    |||::|. ::..|||.|.|.|.|...|......: :|..:....|:.:::|.: ||
Zfish   212 IKKKKQGKISELLIRK-STEGDAGLYTCEAVNSLGKTNTTANLFIINTATSTTPSAKTSSHVTPC 275

  Fly   567 N---FDYCFHNGTC---RMIPDINEVYCRCPTEYFGNRCEN 601
            |   .:||.::|.|   .:.|......||||.|:.|:||::
Zfish   276 NESEKEYCVNHGKCFTLEVTPGNIRRLCRCPNEFTGDRCQH 316

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
vn	NP_523942.2	IGc2	471..538	CDD:197706	26/71 (37%)
vn	NP_523942.2	EGF	566..598	CDD:278437	13/37 (35%)
nrg1	NP_001264015.1	I-set	166..255	CDD:254352	28/90 (31%)
		Ig	178..253	CDD:299845	24/75 (32%)
		PHA03099	257..372	CDD:165381	18/60 (30%)
		Neuregulin	333..718	CDD:280343
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		oto40373
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11100
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X2572
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	4.010