DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment vn and crb2a

DIOPT Version :9

Sequence 1:	NP_523942.2	Gene:	vn / 38657	FlyBaseID:	FBgn0003984	Length:	623	Species:	Drosophila melanogaster
Sequence 2:	NP_001038764.1	Gene:	crb2a / 723994	ZFINID:	ZDB-GENE-060612-1	Length:	1466	Species:	Danio rerio

Alignment Length:	257	Identity:	52/257 - (20%)
Similarity:	93/257 - (36%)	Gaps:	74/257 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly   374 RLQFALSNSSGECDIYRERLMPRGMLRSGN------DLQQASDISYMMFVQQTNPGNFTILGQPM 432
            ||.||:::.  |.|..:..::..|::...:      .|....|||..:.:.:|..|   .|| .:
Zfish  1108 RLLFAMAHP--EHDASQWFVLVDGIIDGSSAPVLAGSLNFLKDISSEVALAETFTG---CLG-AV 1166

  Fly   433 RVTHLVVEAVETAVSENYTQNAEVTKIFSKPSKAIIKHGKKLRIVCEVSGQPPPKVTWFKDEKSI 497
            ||..:.:..|:.      |::.:.|:.:.:|.:.:       .:.|  .|.|..:
Zfish  1167 RVGGVYLPFVDN------TKSPQTTRFWRRPDEHV-------HLGC--FGAPVCR---------- 1206

  Fly   498 NRKRNIYQFKHHKRRSELIVRSFNSSSDAGRYECRAKNKASKAIAKRRI--MIKASPVHFPTDRS 560
                     .|..||....|..||      ::.|:..:.....|.::.|  .|....:|......
Zfish  1207 ---------SHPCRRGGTCVDLFN------KFGCKCPSGWEGNICEKEIDECISGPCLHGKCKDK 1256

  Fly   561 ASGIPC-------------NFD-----YCFHNGTCRMIPDINEVYCRCPTEYFGNRCENKWP 604
            .:|..|             |.|     .|.:.|||  :..:|:..|.||.:|.|.||:..:|
Zfish  1257 LNGFDCLCHPGYAGPTCSENIDDCKGSRCKNGGTC--VDGVNDFTCICPPKYSGTRCQYNYP 1316

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
vn	NP_523942.2	IGc2	471..538	CDD:197706	10/66 (15%)
vn	NP_523942.2	EGF	566..598	CDD:278437	13/49 (27%)
crb2a	NP_001038764.1	EGF_CA	32..69	CDD:238011
		EGF_CA	97..133	CDD:238011
		EGF_CA	<144..172	CDD:238011
		EGF_CA	174..210	CDD:238011
		EGF_CA	212..248	CDD:238011
		EGF_CA	251..286	CDD:238011
		EGF_CA	288..325	CDD:238011
		EGF_CA	327..363	CDD:238011
		EGF_CA	365..416	CDD:238011
		EGF_CA	419..455	CDD:238011
		Laminin_G_2	580..714	CDD:280389
		LamG	786..929	CDD:238058
		EGF_CA	<969..997	CDD:238011
		LamG	1046..1168	CDD:238058	15/65 (23%)
		EGF_CA	<1208..1237	CDD:238011	8/34 (24%)
		EGF_CA	1240..1273	CDD:238011	5/32 (16%)
		EGF_CA	1276..1312	CDD:238011	13/37 (35%)
		EGF_CA	1320..1353	CDD:238011
		EGF_CA	1356..1391	CDD:238011
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910