Protein Alignment vn and vn

DIOPT Version :10

• Sequence 1: NP_523942.2
• Gene: vn / 38657
• FlyBaseID: FBgn0003984
• Length: 623
• Species: Drosophila melanogaster
• Sequence 2: XP_061508573.1
• Gene: vn / 4576279
• VectorBaseID: AGAMI1_010695
• Length: 616
• Species: Anopheles gambiae
• Alignment Length: 675
• Identity: 208/675 - (30%)
• Similarity: 288/675 - (42%)
• Gaps: 176/675 - (26%)

  Fly     5 HLRKWSLKTKKQLMPLILLIISYMLLLNTCVLSSSATTQQQQQQQQQQQHL--PRLWEGSAEESS 67
            :|||||  ..|.||.|.|.|:.:|  .:.|  .|:||           .||  |
Mosquito     2 YLRKWS--PVKYLMYLWLAILVWM--FSRC--DSAAT-----------MHLAPP----------- 38

  Fly    68 YYIPLSSDNGSGSSESSAESGSSSSRSSSNNIDNNILSRLLSLNSNSLSSRSNVKLKPATVFDAG 132
               |..|....|:     ..|.|||.|||::|.::  .|.:|.:.::.:|.|:....||...:.|
Mosquito    39 ---PYHSSGFQGT-----PGGHSSSISSSSSISSS--GRYVSDSRSTTTSVSSHTSAPAHRVEEG 93

  Fly   133 SSTPAQQEQHVAAVPEQQQQQQQQQQSMQKVPNTLINSQIYNLLYNGMPSEAASSKMRRHIQPSQ 197
            .|..|                         :|..|..|       :|.||.|:||       |..
Mosquito    94 LSGGA-------------------------IPPRLYTS-------SGAPSTASSS-------PPP 119

  Fly   198 LP------------HQP-------ESRAQLPSNYSSRPAVRSYLIESYEMPESMLEDRSPEQAA- 242
            ||            .||       .|..||....|:......   ....:|.:.|.:..|:..|
Mosquito   120 LPLLVLPRSAPWPWQQPAASRGSEASAVQLLRRTSANTKAEQ---PGRTLPANQLSELDPQPIAL 181

  Fly   243 -------RSRRDGSNTNGSRQ-QQRTGHRQQLQQDKRD-HRRQ-RQDQQKEQRQQ----QQQRQH 293
                   .|..:.|..|..|. |||...:.:|:.::|. |||: |.......|..    .:.|:.
Mosquito   182 PASAGEESSTGNSSIINAERSLQQRWASQMRLKGERRRLHRRRWRTANNSSSRSSSLLASRNRRD 246

  Fly   294 KS-------GNKHQQQQQQRRKHQRKHQRYN---------RYCSARDPAQLAFAAPTVFQGVFKS 342
            .:       |:.........::|..:.||.|         |||||||||.|||.||.|.:...||
Mosquito   247 SALLPTGYGGSVRPASTGSGQQHPVRPQRRNGTGGGPGQRRYCSARDPATLAFEAPIVCEAKVKS 311

  Fly   343 MSADRRVNFSATMKVEKVYKQQHDLQLP--------TLVRLQFALSNSSGECDIYRERLMPRGML 399
            || |||..|:||.::..::|      ||        ..|||||.|: ::.||||:|.:...||.:
Mosquito   312 MS-DRRPIFAATFEILALHK------LPPKGRPLRGLTVRLQFNLT-TANECDIFRGKFRERGFV 368

  Fly   400 RSGNDLQQASDISYMMFVQQTNPG----NFTILGQPMRVTHLVVEAVETAVSENYTQNAEVTKIF 460
            |...:|.:.    |.:|::   |.    ||||||||:|.|......|...|:.||.....:.  |
Mosquito   369 REELELGKV----YFLFLK---PNMRYTNFTILGQPIRKTKRSEGGVLQGVNPNYGTRPAIH--F 424

  Fly   461 SKPSKAIIKHGKKLRIVCEVSGQPPPKVTWFKDEKSINRKRNIYQFKHHKRRSELIVRSFN-SSS 524
            ..|:...:: ||::|:||:|.|||||||.||||::.|||....|...|.|:|||||:  || |::
Mosquito   425 ITPNVTRVE-GKRVRLVCKVGGQPPPKVAWFKDKRLINRNATKYAQVHLKKRSELII--FNTSTT 486

  Fly   525 DAGRYECRAKNK--ASKAIAKRRIMIKASPVHFPTDRSASGIPC----NFDYCFHNGTCRMIPDI 583
            |:|.|||||||:  .|.......:.|.......|...|.|   |    ..|:|.:.|||..|..|
Mosquito   487 DSGEYECRAKNRYNNSSVFNSTHVKITLPKATIPAVYSRS---CADSHRDDFCHNGGTCFNIDSI 548

  Fly   584 NEVYCRCPTEYFGNRCENKWPDSRY 608
            .|:.|.||..:.|.|||||  ||.:
Mosquito   549 GELACYCPKGFSGFRCENK--DSEF 571

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
vn	NP_523942.2	Ig	462..540	CDD:472250	42/80 (53%)
		Ig strand B	474..478	CDD:409353	1/3 (33%)
		Ig strand C	487..491	CDD:409353	2/3 (67%)
		Ig strand E	513..517	CDD:409353	3/3 (100%)
		Ig strand F	528..533	CDD:409353	3/4 (75%)
		EGF	566..598	CDD:394967	13/35 (37%)
vn	XP_061508573.1	None