DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment vn and NRG1

DIOPT Version :9

Sequence 1:	NP_523942.2	Gene:	vn / 38657	FlyBaseID:	FBgn0003984	Length:	623	Species:	Drosophila melanogaster
Sequence 2:	NP_001309134.1	Gene:	NRG1 / 3084	HGNCID:	7997	Length:	700	Species:	Homo sapiens

Alignment Length:	198	Identity:	47/198 - (23%)
Similarity:	76/198 - (38%)	Gaps:	49/198 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly   421 NPGNFTILGQ-PMRVTHLVVEAVETAVSENYTQNAEVTKIFSKPSKAIIKHGKKLRIVCEVSGQP 484
            :||.   ||| |:........:.....||.||  :.|::..|:....:...|.|..:..|.|..|
Human   113 DPGG---LGQDPIISLDATAASAVWVSSEAYT--SPVSRAQSESEVQVTVQGDKAVVSFEPSAAP 172

  Fly   485 PPKVTWFKDEKSINRKRNIYQFKHHKRRSELIVRSFNSSSDAGRYECRAKN------KASKAIAK 543
            .||          ||   |:.|            ||..|: |..:....:|      |::.....
Human   173 TPK----------NR---IFAF------------SFLPST-APSFPSPTRNPEVRTPKSATQPQT 211

  Fly   544 RRIMIKASPVHFPTDRSASG----IPC---NFDYCFHNGTCRMIPDI---NEVYCRCPTEYFGNR 598
            ....::.:| ...|..|.:|    :.|   ...:|.:.|.|.|:.|:   :...|:||.|:.|:|
Human   212 TETNLQTAP-KLSTSTSTTGTSHLVKCAEKEKTFCVNGGECFMVKDLSNPSRYLCKCPNEFTGDR 275

  Fly   599 CEN 601
            |:|
Human   276 CQN 278

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
vn	NP_523942.2	IGc2	471..538	CDD:197706	17/72 (24%)
vn	NP_523942.2	EGF	566..598	CDD:278437	11/37 (30%)
NRG1	NP_001309134.1	PHA02887	<236..279	CDD:165214	14/43 (33%)
NRG1	NP_001309134.1	Neuregulin	295..688	CDD:280343
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_28J9V
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm40289
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X2572
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.810