DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment vn and Nrg1

DIOPT Version :9

Sequence 1:	NP_523942.2	Gene:	vn / 38657	FlyBaseID:	FBgn0003984	Length:	623	Species:	Drosophila melanogaster
Sequence 2:	XP_006509122.1	Gene:	Nrg1 / 211323	MGIID:	96083	Length:	884	Species:	Mus musculus

Alignment Length:	242	Identity:	56/242 - (23%)
Similarity:	92/242 - (38%)	Gaps:	55/242 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly   410 DISYMMFVQ-QTN-----PGNFTILGQPMRVTHLVVEAVETAVSENYTQNAEVTKIFSKPSKAII 468
            |..|:.|:: ..|     |..|.....|:.....:.:.|...:.:.......:.::.|:.|.|
Mouse   200 DSRYIFFMEPDANSSGRAPPAFRASFPPLETGRNLKKEVSRVLCKRCALPPRLKEMKSQESAA-- 262

  Fly   469 KHGKKLRIVCEVSGQ-PPPKVTWFKDEKSINRKRNIYQFKHHKR--RSELIVRSFNSSSDAGRYE 530
              |.||.:.||.|.: ...:..|||:...:||:......|..|:  :|||.:.. .|.:|:|.|.
Mouse   263 --GSKLVLRCETSSEYSSLRFKWFKNGNELNRRNKPQNVKIQKKPGKSELRINK-ASLADSGEYM 324

  Fly   531 CRAKNKASKAIAKRRIMI--------------------KASPVHF-----------PTDRSASG- 563
            |:..:|.....|...|.|                    ..||:..           .|..|.:|
Mouse   325 CKVISKLGNDSASANITIVESNDLTTGMSASTERPYVSSESPIRISVSTEGANTSSSTSTSTTGT 389

  Fly   564 ---IPC---NFDYCFHNGTCRMIPDI---NEVYCRCPTEYFGNRCEN 601
               |.|   ...:|.:.|.|.|:.|:   :...|:||.|:.|:||:|
Mouse   390 SHLIKCAEKEKTFCVNGGECFMVKDLSNPSRYLCKCPNEFTGDRCQN 436

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
vn	NP_523942.2	IGc2	471..538	CDD:197706	22/69 (32%)
vn	NP_523942.2	EGF	566..598	CDD:278437	11/37 (30%)
Nrg1	XP_006509122.1	Ig_Pro_neuregulin-1	266..340	CDD:143303	21/74 (28%)
		EGF	403..433	CDD:333761	10/29 (34%)
		Neuregulin	511..866	CDD:366946
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_28J9V
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X2572
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.810