DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment vn and VCAN

DIOPT Version :9

Sequence 1:	NP_523942.2	Gene:	vn / 38657	FlyBaseID:	FBgn0003984	Length:	623	Species:	Drosophila melanogaster
Sequence 2:	NP_004376.2	Gene:	VCAN / 1462	HGNCID:	2464	Length:	3396	Species:	Homo sapiens

Alignment Length:	757	Identity:	125/757 - (16%)
Similarity:	215/757 - (28%)	Gaps:	269/757 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly    38 SSATTQQQQQQQQQ--------QQHLPRLWEGSAEES------SYYIPLSSDNGSGSSESSAESG 88
            :|||||..:|:...        ::| |.:....|..:      |..:||.|:....|.:.:  |.
Human  2444 TSATTQATRQESSTTFVSDGSLEKH-PEVPSAKAVTADGFPTVSVMLPLHSEQNKSSPDPT--ST 2505

  Fly    89 SSSSRSSSNNIDNNILSRLLSLNSNSLSSRSNVKLKPA--------------------------- 126
            .|::.|...:.|.:...|......::|  :.|.| ||.
Human  2506 LSNTVSYERSTDGSFQDRFREFEDSTL--KPNRK-KPTENIIIDLDKEDKDLILTITESTILEIL 2567

  Fly   127 --------TVFDAGSSTPAQQ---------EQHVAAVP-EQQQQQQQQQQSMQKVPNTLINSQIY 173
                    |:.|...:.|..:         :..|.:.| :...:.......:|::....:|..:.
Human  2568 PELTSDKNTIIDIDHTKPVYEDILGMQTDIDTEVPSEPHDSNDESNDDSTQVQEIYEAAVNLSLT 2632

  Fly   174 NLLYNGMPSEAASSKMRRHIQP------SQLPHQ----------PESRAQLP---SNYSSRPAVR 219
            ...:.|.....||.....|.:.      |||.|.          |.:..:|.   ...:|.|..|
Human  2633 EETFEGSADVLASYTQATHDESMTYEDRSQLDHMGFHFTTGIPAPSTETELDVLLPTATSLPIPR 2697

  Fly   220 SYL-----IESYEMPESMLEDR------SPEQAARSRRDGSNTNGSRQQQRTGHRQQLQQDKRDH 273
            ...     ||..:.....|:|.      |..||...:.:...|.|  |.:||
Human  2698 KSATVIPEIEGIKAEAKALDDMFESSTLSDGQAIADQSEIIPTLG--QFERT------------- 2747

  Fly   274 RRQRQDQQKEQRQQQQQRQHKSGNKHQQQQQQRRKHQRKHQRYNRYCSARDPAQLAFAAPTVFQG 338
              |.:.:.|:......|.:..||.:.....         |..|....:.....|.....|.|.:|
Human  2748 --QEEYEDKKHAGPSFQPEFSSGAEEALVD---------HTPYLSIATTHLMDQSVTEVPDVMEG 2801

  Fly   339 VFKSMSADRRVNFSATMKVEKVYKQQHDLQLPTLVRLQFALSNSSGECDIYRERLMPRGMLRSGN 403
            .......|..:..|...|:..        |.|:.....::.|.:||..:|.:...:|      |.
Human  2802 SNPPYYTDTTLAVSTFAKLSS--------QTPSSPLTIYSGSEASGHTEIPQPSALP------GI 2852

  Fly   404 DLQQASDISYMMFVQQTNPGNFTILGQPMRVTHLVVEAVETAVSENYTQNAE------------- 455
            |:.     |.:|..|.:           .:..|:.:||.....||.|....|
Human  2853 DVG-----SSVMSPQDS-----------FKEIHVNIEATFKPSSEEYLHITEPPSLSPDTKLEPS 2901

  Fly   456 --------VTKIFSKPSKAIIKHGKKL------RIVCEVSGQ-----PPPK-------------- 487
                    :.::.:.|::.|...|.::      :...:|||:     |..|
Human  2902 EDDGKPELLEEMEASPTELIAVEGTEILQDFQNKTDGQVSGEAIKMFPTIKTPEAGTVITTADEI 2966

  Fly   488 ------------------------VTWFKDEKS----INRKRNIYQFKHHKRRSELIVRSFNSSS 524
                                    |.|...:.|    ::....|     :......::|..:|:.
Human  2967 ELEGATQWPHSTSASATYGVEAGVVPWLSPQTSERPTLSSSPEI-----NPETQAALIRGQDSTI 3026

  Fly   525 DAGRYECRAKNKASKAIAKRRIMIKASPVHFPT-----------------------DRSASG--- 563
            .|...:..|:      |.........:||.|.|                       :.|..|
Human  3027 AASEQQVAAR------ILDSNDQATVNPVEFNTEVATPPFSLLETSNETDFLIGINEESVEGTAI 3085

  Fly   564 -IP----CNFDYCFHNGTCRMIPDINEVYCRCPTEYFGNRCE 600
             :|    |..:.|.:.|||  .|......|.|...|.|::||
Human  3086 YLPGPDRCKMNPCLNGGTC--YPTETSYVCTCVPGYSGDQCE 3125

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
vn	NP_523942.2	IGc2	471..538	CDD:197706	14/119 (12%)
vn	NP_523942.2	EGF	566..598	CDD:278437	10/31 (32%)
VCAN	NP_004376.2	IG_like	29..147	CDD:214653
		Ig_Versican	36..151	CDD:143309
		Link_domain_CSPGs_modules_1_3	150..244	CDD:239594
		Link_domain_CSPGs_modules_2_4	251..346	CDD:239597
		GAG-alpha (glucosaminoglycan attachment domain)	348..1335
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	420..439
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	603..622
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	807..829
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1126..1154
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1277..1316
		GAG-beta	1336..3089		112/717 (16%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1420..1497
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1510..1539
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1717..1737
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1759..1789
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1962..1994
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	2107..2134
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	2168..2188
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	2371..2396
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	2445..2473		8/28 (29%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	2493..2518		5/26 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	2598..2617		2/18 (11%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	2834..2856		7/32 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	2881..2905		3/23 (13%)
		EGF_CA	3091..3125	CDD:238011	10/35 (29%)
		EGF_CA	3127..3163	CDD:238011
		CLECT_CSPGs	3169..3292	CDD:153058
		CCP	3296..3352	CDD:153056
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	3371..3396
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910