DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment vn and NRG3

DIOPT Version :9

Sequence 1:	NP_523942.2	Gene:	vn / 38657	FlyBaseID:	FBgn0003984	Length:	623	Species:	Drosophila melanogaster
Sequence 2:	XP_016871062.1	Gene:	NRG3 / 10718	HGNCID:	7999	Length:	747	Species:	Homo sapiens

Alignment Length:	485	Identity:	91/485 - (18%)
Similarity:	176/485 - (36%)	Gaps:	138/485 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    63 AEESSYYIPLSSDNGSGSSESSAESGSSSSRSSSNNIDNNILSRLLSLN---SNSLSSRSNVKLK 124
            ::.||:  |.:.:..:.::.:::.:..|:..::|:...|.|.:||.::.   :.....|..::..
Human   116 SKPSSF--PKAMETTTTTTSTTSPATPSAGGAASSRTPNRISTRLTTITRAPTRFPGHRVPIRAS 178

  Fly   125 PATVFDAGSSTPAQQEQHVAAVPEQQQQQQQQQQSMQKVPNTLINSQIYNLLYNGMPSEAASSKM 189
            |.:.....::.||                        .||:|.            .|..::|:..
Human   179 PRSTTARNTAAPA------------------------TVPSTT------------APFFSSSTLG 207

  Fly   190 RRHIQPSQLPHQPESRAQLPSNYSSRPAVRSYLIESYEMPESMLEDRSPEQAARSRRDGSNTNGS 254
            .|    ..:|..|.::| :||..::..|..|||.:|  .|...|   ||.|.|.|....|:::.:
Human   208 SR----PPVPGTPSTQA-MPSWPTAAYATSSYLHDS--TPSWTL---SPFQDAASSSSSSSSSAT 262

  Fly   255 RQQQRTGHRQQLQQDKRDHRRQRQDQQKEQRQQQQQRQHKSGNKHQQQQQQRRKHQR-KHQRY-- 316
            .....|....:.:  .||.|........:.|..::|:|.:....:..::.:..|..| |...|
Human   263 TTTPETSTSPKFR--PRDRRHAIHGNMGKTRVVRRQKQEQDTTTYSTERSEHFKPCRDKDLAYCL 325

  Fly   317 --------------NRYCSARDPAQLAFAAPTVFQGV--------FKSMSADRR----VNFSATM 355
                          :::|..::.          :|||        ..|:.:|..    :.|   |
Human   326 NDGECFVIETLTGSHKHCRCKEG----------YQGVRCDQFLPKTDSILSDPTDHLGIEF---M 377

  Fly   356 KVEKVYKQQHDLQLPTLVRLQFALSNSSGECDIYRERLMPRGMLRSG---NDLQQASDISYMMFV 417
            :.|:||::|             .||.|   |.|:  .::..||..:.   ...:||..|...:.|
Human   378 ESEEVYQRQ-------------VLSIS---CIIF--GIVIVGMFCAAFYFKSKKQAKQIQEQLKV 424

  Fly   418 QQTNPGNFTILGQPMRVTHLVVEAVET-AVSENYTQNAEVTKIFSKPSKAIIKHGKKLRIVCEVS 481
            .| |..::::            :|..| |.|||..::....:.:||..:..:...:|:.....|.
Human   425 PQ-NGKSYSL------------KASSTMAKSENLVKSHVQLQNYSKVERHPVTALEKMMESSFVG 476

  Fly   482 GQPPPKVTWFKDEKSINRKRNIYQFKHHKR 511
            .|..|:|.        :..|.....|||.|
Human   477 PQSFPEVP--------SPDRGSQSVKHHSR 498

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
vn	NP_523942.2	IGc2	471..538	CDD:197706	10/41 (24%)
vn	NP_523942.2	EGF	566..598	CDD:278437
NRG3	XP_016871062.1	None
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR11100
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	2.010