Protein Alignment vn and Nrg2

DIOPT Version :9

• Sequence 1: NP_523942.2
• Gene: vn / 38657
• FlyBaseID: FBgn0003984
• Length: 623
• Species: Drosophila melanogaster
• Sequence 2: NP_001369349.1
• Gene: Nrg2 / 100042150
• MGIID: 1098246
• Length: 859
• Species: Mus musculus
• Alignment Length: 582
• Identity: 132/582 - (22%)
• Similarity: 192/582 - (32%)
• Gaps: 236/582 - (40%)

  Fly    56 PRLWEGSAEESSYYIPLSSDNGSGSSESSAESGSSSSRSSSNNIDNNILSRLLSLNSNSLSSRSN 120
            |.|.:......||..   ||:.|.::.||..|.|||||:||              :|||.||.|
Mouse    11 PPLEKARCSSYSYSY---SDSSSSTTSSSRSSSSSSSRNSS--------------SSNSSSSES- 57

  Fly   121 VKLKPATVFDAGSSTPAQQEQHVAAVPEQQQQQQQQQQSMQKVPNTLINSQIYNLLYNGMPSEAA 185
                      :||::.:......||.||.:.|.|.|.:| .........|:           .||
Mouse    58 ----------SGSNSGSSSIFRPAAPPEPRPQPQPQPRS-PAARRAAARSR-----------AAA 100

  Fly   186 SSKMRRHIQP--SQLPHQPESRAQLPSNYSSRPAVRSYLIESYEMP---ESMLEDRSPEQAARSR 245
            :..|||...|  |.|........     ||  |:::|...::|:.|   |..::..:|
Mouse   101 AGGMRRDPAPGFSMLLFGVSLAC-----YS--PSLKSVQDQAYKAPVVVEGKVQGLAP------- 151

  Fly   246 RDGSNTNGSRQQQRTGHRQQLQQDKRDHRRQRQDQQKEQRQQQQQRQHKSGNKHQQQQQQRRKHQ 310
            ..||::|.:|:...:|
Mouse   152 AGGSSSNSTREPPASG------------------------------------------------- 167

  Fly   311 RKHQRYNRYCSARDPAQLAFAAPTVFQGVFKSMSADRRVNFSATMKVEKVYKQQHDLQLPTLVRL 375
                                                 ||   |.:||
Mouse   168 -------------------------------------RV---ALVKV------------------ 174

  Fly   376 QFALSNSSGECDIYRERLMPRGMLRSGNDLQQASDIS------------YMMFVQQTNPGNFTIL 428
                              :.:..||||. ||:...||            |:.|::.|.
Mouse   175 ------------------LDKWPLRSGG-LQREQVISVGSCAPLERNQRYIFFLEPTE------- 213

  Fly   429 GQPMRVTHLVVEAVETAVSENYTQ-NAEVTKIF-----SKPSKAIIKH-----GKKLRIVCE-VS 481
             ||     ||.:.....|..|... ..||.||.     ::|....:|.     |:|..:.|| .:
Mouse   214 -QP-----LVFKTAFAPVDPNGKNIKKEVGKILCTDCATRPKLKKMKSQTGEVGEKQSLKCEAAA 272

  Fly   482 GQPPPKVTWFKDEKSINRKRNI-YQFKHHKRRSELIVRSFNS--SSDAGRYECRAKNKASKAIAK 543
            |.|.|...||||.|.:||.|:| .::.:.::.|.|   .||.  ..|||.|.|.|:|...|...:
Mouse   273 GNPQPSYRWFKDGKELNRSRDIRIKYGNGRKNSRL---QFNKVRVEDAGEYVCEAENILGKDTVR 334

  Fly   544 RRIMIKASPVHFPTDRSASG--IPCN---FDYCFHNGTCRMIPDINEVYCRCPTEYFGNRCE 600
            .|:.:.:...   |..|.||  ..||   ..||.:.|.|..|..||::.|:||..|.|:||:
Mouse   335 GRLHVNSVST---TLSSWSGHARKCNETAKSYCVNGGVCYYIEGINQLSCKCPVGYTGDRCQ 393

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
vn	NP_523942.2	IGc2	471..538	CDD:197706	27/70 (39%)
		EGF	566..598	CDD:278437	14/34 (41%)
Nrg2	NP_001369349.1	Ig_Pro_neuregulin	248..339	CDD:409408	31/93 (33%)
		Ig strand B	264..268	CDD:409408	0/3 (0%)
		Ig strand C	278..282	CDD:409408	0/3 (0%)
		Ig strand E	305..309	CDD:409408	2/6 (33%)
		Ig strand F	319..324	CDD:409408	2/4 (50%)
		Ig strand G	332..335	CDD:409408	0/2 (0%)
		PHA02887	<354..397	CDD:165214	16/40 (40%)
		Neuregulin	443..840	CDD:396641

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_28J9V
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		oto91929
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11100
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R8848
SonicParanoid	1	1.000	-	-		X2572
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	5.940