DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment vn and nrg2a

DIOPT Version :9

Sequence 1:	NP_523942.2	Gene:	vn / 38657	FlyBaseID:	FBgn0003984	Length:	623	Species:	Drosophila melanogaster
Sequence 2:	XP_005161385.1	Gene:	nrg2a / 100006951	ZFINID:	ZDB-GENE-070615-10	Length:	710	Species:	Danio rerio

Alignment Length:	307	Identity:	78/307 - (25%)
Similarity:	133/307 - (43%)	Gaps:	73/307 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly   329 AFAAPTVFQGVFKSMSADRRVN---FSATMKVEKVYKQQHDLQLPTLVRLQFALSNSSGECDIYR 390
            |:.:..|.:|  |..||.:.|:   :|..:||..|:.:                 ||.|   :.|
Zfish    32 AYRSAVVIEG--KVQSAPQNVSAEPYSVNVKVLDVWPR-----------------NSGG---LER 74

  Fly   391 ERLMPRGMLRSGNDLQQA-SDISYMMFVQQTNPGNFTILGQPMRVTHLVVEA----VETAVSENY 450
            |:|:..|...|.....:. .:..|:.|:..|:        :|     ||.:|    ::|: .:|.
Zfish    75 EQLVTVGEFGSEAPCTKVKKNHKYIFFMDPTD--------EP-----LVFKASFAPLDTS-GKNL 125

  Fly   451 TQNAEVTKIFSK-----PSKAIIKH------GKKLRIVCEVSGQPPPKVTWFKDEKSINRKRNIY 504
            .:  :|.:|..:     ||...:|:      |.:|.:.||.:|.|.|:..|:||...:.|.:.|
Zfish   126 KK--DVGRILCEDCAAFPSLRRMKNPVLADEGSRLIVKCEATGSPAPEYKWYKDGAELKRSKEI- 187

  Fly   505 QFKHHKRRSELIVRSFNSSSDAGRYECRAKNKASKA-----IAKRRIMIKASPVHFPTDRSASGI 564
            :.:::|:.|::.:.| ....|:|.|.|.|:|...||     :..:.|....||      .|....
Zfish   188 KIRNNKKNSKVQIGS-AKLEDSGNYTCVAENILGKANGTSTVHVQSITTTVSP------GSGHAR 245

  Fly   565 PCN---FDYCFHNGTCRMIPDINEVYCRCPTEYFGNRCENKWPDSRY 608
            .||   ..||.:.|.|..|..||::.|:||.:|.|:||:.....|.|
Zfish   246 RCNDTEKTYCVNGGDCYYIHGINQLSCKCPNDYTGDRCQTSVMASFY 292

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
vn	NP_523942.2	IGc2	471..538	CDD:197706	21/66 (32%)
vn	NP_523942.2	EGF	566..598	CDD:278437	14/34 (41%)
nrg2a	XP_005161385.1	IG_like	149..230	CDD:214653	23/82 (28%)
		Ig_Pro_neuregulin	158..228	CDD:143227	22/71 (31%)
		PHA03099	220..341	CDD:165381	24/79 (30%)
		Neuregulin	302..698	CDD:280343
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_28J9V
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11100
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R8848
SonicParanoid	1	1.000	-	-		X2572
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	5	4.940