DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment mad2 and mad2l1

DIOPT Version :9

Sequence 1:	NP_647991.1	Gene:	mad2 / 38656	FlyBaseID:	FBgn0035640	Length:	207	Species:	Drosophila melanogaster
Sequence 2:	NP_001017739.1	Gene:	mad2l1 / 550434	ZFINID:	ZDB-GENE-030515-3	Length:	202	Species:	Danio rerio

Alignment Length:	194	Identity:	89/194 - (45%)
Similarity:	136/194 - (70%)	Gaps:	4/194 - (2%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 ITLKGSAQIIVEYLKYGINSILFQRGIYPAEDFNNTQQYGLTILMSKDPKIKTFLQNVLSQTEEW 75
            |||||||:::.|:..:||||||:||||||||.|....||.:::.::.|.|:|.:|.||:||.:||
Zfish     8 ITLKGSAELVAEFFSFGINSILYQRGIYPAETFTRVTQYDMSLQLTTDTKLKNYLTNVISQLKEW 72

  Fly    76 LSKNMINKISMVITNAHTKEVLECWDFNMQAELGDGDISDPTKATTTKELSRIQNEIRDVMRQIS 140
            |.:..:.|:.:|||...|.||||.|.|::|.:....:.|.|.:    |.:..||.|||.|:|||:
Zfish    73 LFECTVQKLVVVITCLETNEVLERWQFDIQCDKTAKESSAPRE----KSIKAIQEEIRSVIRQIT 133

  Fly   141 ATVSYLPLLDCICTFDIMIHTLQNTELPAKWDETGAIVIQNPQAVQLRSFSTGLHKVDTVVNYK 204
            |||::||||:..|..|::|:|.::.|:|.:|:|:|..:|...:.|:||||:|.:|||:::|.||
Zfish   134 ATVTFLPLLETACALDLLIYTDKDLEVPEQWEESGPQLIDQSEEVRLRSFTTSIHKVNSMVAYK 197

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mad2	NP_647991.1	HORMA	13..195	CDD:280464	81/181 (45%)
mad2l1	NP_001017739.1	HORMA	10..188	CDD:280464	81/181 (45%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170578993
Domainoid	1	1.000	154	1.000	Domainoid score	I4234
eggNOG	1	0.900	-	-		E1_KOG3285
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H1768
Inparanoid	1	1.050	188	1.000	Inparanoid score	I3902
OMA	1	1.010	-	-		QHG53959
OrthoDB	1	1.010	-	-		D1197019at2759
OrthoFinder	1	1.000	-	-		FOG0005018
OrthoInspector	1	1.000	-	-		oto40249
orthoMCL	1	0.900	-	-		OOG6_103574
Panther	1	1.100	-	-	LDO	PTHR11842
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R677
SonicParanoid	1	1.000	-	-		X4198
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	16	15.800