DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment mad2 and mdf-2

DIOPT Version :9

Sequence 1:	NP_647991.1	Gene:	mad2 / 38656	FlyBaseID:	FBgn0035640	Length:	207	Species:	Drosophila melanogaster
Sequence 2:	NP_001023563.1	Gene:	mdf-2 / 177046	WormBaseID:	WBGene00003161	Length:	203	Species:	Caenorhabditis elegans

Alignment Length:	200	Identity:	89/200 - (44%)
Similarity:	139/200 - (69%)	Gaps:	7/200 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 TKNCITLKGSAQIIVEYLKYGINSILFQRGIYPAEDFNNTQQYGLTILMSKDPKIKTFLQNVLSQ 71
            |:|.|:||||||::.|:..:|:||||:||.:||::.|...::||||:.::.:.|::.|:..:|.|
Worm     6 TQNAISLKGSAQLVKEFFHFGLNSILYQRALYPSDSFKREKKYGLTLWVAHEKKLQAFMDPLLQQ 70

  Fly    72 TEEWLSKNMINKISMVITNAHTKEVLECWDFNMQAE--LGDGDISDPTKATTTKELSRIQNEIRD 134
            .|.||:|..:.::.|||:...||||:|.|.|::..|  ..:|:     .|...||..:|:.||.|
Worm    71 VEYWLAKRQLKRLVMVISEVKTKEVVERWQFDIHTENLAEEGE-----NAHRVKEEKKIRQEISD 130

  Fly   135 VMRQISATVSYLPLLDCICTFDIMIHTLQNTELPAKWDETGAIVIQNPQAVQLRSFSTGLHKVDT 199
            |:|||:|:||:||||:...:||::|:|.::|:.|..|.|:||.:|||.:.||||||||.:|.|:|
Worm   131 VIRQITASVSFLPLLEEPVSFDVLIYTGKDTQAPEDWTESGACLIQNSETVQLRSFSTSVHSVNT 195

  Fly   200 VVNYK 204
            .|.||
Worm   196 NVQYK 200

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mad2	NP_647991.1	HORMA	13..195	CDD:280464	80/183 (44%)
mdf-2	NP_001023563.1	HORMA	15..191	CDD:367025	77/180 (43%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160158646
Domainoid	1	1.000	163	1.000	Domainoid score	I2416
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H1768
Inparanoid	1	1.050	184	1.000	Inparanoid score	I2621
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53959
OrthoDB	1	1.010	-	-		D1197019at2759
OrthoFinder	1	1.000	-	-		FOG0005018
OrthoInspector	1	1.000	-	-		oto19560
orthoMCL	1	0.900	-	-		OOG6_103574
Panther	1	1.100	-	-	LDO	PTHR11842
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R677
SonicParanoid	1	1.000	-	-		X4198
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	14	13.940