DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment kri and UCKL1

DIOPT Version :9

Sequence 1:	NP_001261451.1	Gene:	kri / 38655	FlyBaseID:	FBgn0035639	Length:	261	Species:	Drosophila melanogaster
Sequence 2:	XP_024307683.1	Gene:	UCKL1 / 54963	HGNCID:	15938	Length:	612	Species:	Homo sapiens

Alignment Length:	339	Identity:	80/339 - (23%)
Similarity:	118/339 - (34%)	Gaps:	144/339 - (42%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 GSP----SSSGSQSEEGSSSSDHQQPQQEAQEQEQQLH-----TPTHAH---AAVPAATSEEILA 56
            |:|    :....:.||.::.:.|....|...:|.:::|     |...||   |.:||
Human   316 GTPVPPAAPDAERPEEHAAGTGHAHHHQGQGDQSRRVHLLLQETDAAAHRARALLPA-------- 372

  Fly    57 EYGSNLKLLECNSQVAELLTILRDKNTTRSDFKFYADRLIRLVIEESLNQLPYTHCDVETPTGAI 121
                              |:.||     |:|                             |.||.
Human   373 ------------------LSGLR-----RTD-----------------------------PAGAG 385

  Fly   122 YEG--LKYRSGNC-------------------------GVSIIRSGEAMEQGLRDCCRSIRIGKI 159
            ..|  |...:|.|                         ||||:|:||.||..||..|:.:|||.|
Human   386 LCGQVLCGEAGTCLGTPGRGTGCWGGMWALSLPSPQITGVSILRAGETMEPALRAVCKDVRIGTI 450

  Fly   160 LVESDANTHEARVV------------------------------------YARFPDDIGSRQVLL 188
            |::::..|.|..|.                                    |.|.|.||....|:|
Human   451 LIQTNQLTGEPEVPGGSRGDEPGGRGQRELTARGRREPHLQPDPCCPQLHYLRLPKDISDDHVIL 515

  Fly   189 MYPIMSTGNTVLQAVNVLREHGVPESCIILSNLFCTPIAARTVVNAFPKLKILT-------SELH 246
            |...:|||...:.||.||.:|.|||..|.|.:|....:...:|..|||:::|:|       ::|.
Human   516 MDCTVSTGAAAMMAVRVLLDHDVPEDKIFLLSLLMAEMGVHSVAYAFPRVRIITTAVDKRVNDLF 580

  Fly   247 PVAP--NHFGQKYF 258
            .:.|  .:||.:||
Human   581 RIIPGIGNFGDRYF 594

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
kri	NP_001261451.1	UPRTase	70..245	CDD:291353	60/244 (25%)
UCKL1	XP_024307683.1	UMPK	101..307	CDD:238981
UCKL1	XP_024307683.1	UPRTase	<417..596	CDD:317125	54/178 (30%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D929897at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100147
Panther	1	1.100	-	-	O	PTHR10285
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1606
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	4.950