DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment S6k and RPS6KA4

DIOPT Version :10

Sequence 1:NP_523941.2 Gene:S6k / 38654 FlyBaseID:FBgn0283472 Length:490 Species:Drosophila melanogaster
Sequence 2:NP_003933.1 Gene:RPS6KA4 / 8986 HGNCID:10433 Length:772 Species:Homo sapiens


Alignment Length:427 Identity:198/427 - (46%)
Similarity:261/427 - (61%) Gaps:39/427 - (9%)


- Green bases have known domain annotations that are detailed below.


  Fly    27 DSDDDRIELDDVDLEPELCINLHQDTEGQETIQLCEENVNPGKIKLGPKDFELKKVLGKGGYGKV 91
            |.|||           |.|         ...:::.|.|:...:.|:..::|||.||||.|.||||
Human     3 DEDDD-----------ESC---------AVELRITEANLTGHEEKVSVENFELLKVLGTGAYGKV 47

  Fly    92 FQVRKTAGRDANKYFAMKVLKKASIVTNQKDTAHTRAERNILEAVKH-PFIVELVYAFQTDGKLY 155
            |.|||..|.||.|.:|||||:||::|...|...|||.||::||.|:. ||:|.|.||||||.||:
Human    48 FLVRKAGGHDAGKLYAMKVLRKAALVQRAKTQEHTRTERSVLELVRQAPFLVTLHYAFQTDAKLH 112

  Fly   156 LILEYLSGGELFMHLEREGIFLEDTTCFYLSEIILALGHLHKLGIIYRDLKPENILLDAQGHVKL 220
            |||:|:||||:|.||.:...|.|.....|..||:|||.|||||||||||||.||:|||::||:.|
Human   113 LILDYVSGGEMFTHLYQRQYFKEAEVRVYGGEIVLALEHLHKLGIIYRDLKLENVLLDSEGHIVL 177

  Fly   221 TDFGLCKEHI-QEGIVTHTFCGTIEYMAPEIL-TRSGHGKAVDWWSLGALMFDMLTGVPPFTAEN 283
            |||||.||.: :|...|.:||||||||||||: :::||||||||||||.|:|::|||..|||.|.
Human   178 TDFGLSKEFLTEEKERTFSFCGTIEYMAPEIIRSKTGHGKAVDWWSLGILLFELLTGASPFTLEG 242

  Fly   284 RKKT----IETILKAKLNLPAYLTPEARDLVRRLMKRQEPQRLGSGPEDAAAVQIHPFFKHVNWD 344
            .:.|    ...|||.....|..:.|.|:||::||:.:...:|||:||:.|..|:.||||:.::|.
Human   243 ERNTQAEVSRRILKCSPPFPPRIGPVAQDLLQRLLCKDPKKRLGAGPQGAQEVRNHPFFQGLDWV 307

  Fly   345 DVLARRLEPPIKPLLRSEDDVSQFDTRFTRQIPVDSPDDTTLSESANLIFQGFTYVAPSILEDMH 409
            .:.||::..|.:|.:|||.||..|...|||..||.||..:....... ||||:::||||||.|.:
Human   308 ALAARKIPAPFRPQIRSELDVGNFAEEFTRLEPVYSPPGSPPPGDPR-IFQGYSFVAPSILFDHN 371

  Fly   410 R-----------ANRMPARSPRRTPRQLPDSSFRLQF 435
            .           |...|.|:.......:.||.|..|:
Human   372 NAVMTDGLEAPGAGDRPGRAAVARSAMMQDSPFFQQY 408

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
S6kNP_523941.2 STKc_p70S6K 81..402 CDD:270736 173/327 (53%)
RPS6KA4NP_003933.1 STKc_MSK2_N 32..364 CDD:270765 176/332 (53%)
Protein Kinases, catalytic domain 404..714 CDD:473864 2/5 (40%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 673..696
Required for nuclear targeting and association with MAPK14 725..772
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 728..772
Blue background indicates that the domain is not in the aligned region.

Return to query results.
Submit another query.