Protein Alignment S6k and PKH2

DIOPT Version :10

• Sequence 1: NP_523941.2
• Gene: S6k / 38654
• FlyBaseID: FBgn0283472
• Length: 490
• Species: Drosophila melanogaster
• Sequence 2: NP_014541.1
• Gene: PKH2 / 854053
• SGDID: S000005460
• Length: 1081
• Species: Saccharomyces cerevisiae
• Alignment Length: 549
• Identity: 142/549 - (25%)
• Similarity: 227/549 - (41%)
• Gaps: 119/549 - (21%)

  Fly    23 DKARDSDD--DRIELDDVDLEPEL-----CINLHQDTEGQETIQLCEENVNPGKIKLGPKDFELK 80
            |...|::|  |:..||::...|.:     .:.:..|:..|:.|...........||.|.|||:..
Yeast   118 DNDYDNNDINDQKTLDNIAGSPHMEKNRNKVKIEHDSSSQKPIAKESSKAQKNIIKKGIKDFKFG 182

  Fly    81 KVLGKGGYGKVFQVRKTAGRDANKYFAMKVLKKASIVTNQKDTAHTRAERNILEAVKH-PFIVEL 144
            .|:|.|.|..|......   |..|.:|.|||.|..:: .||...:...|:..|:.:.: |.:|.|
Yeast   183 SVIGDGAYSTVMLATSI---DTKKRYAAKVLNKEYLI-RQKKVKYVSIEKTALQKLNNSPSVVRL 243

  Fly   145 VYAFQTDGKLYLILEYLSGGELFMHLEREGIFLEDTTC--FYLSEIILALGHLHKLGIIYRDLKP 207
            ...||.:..||.:|||...|:....:::.|..  |.||  :|.::||.|:.:||..|||:||:||
Yeast   244 FSTFQDESSLYFLLEYAPNGDFLSLMKKYGSL--DETCARYYAAQIIDAIDYLHSNGIIHRDIKP 306

  Fly   208 ENILLDAQGHVKLTDFG-----------LCKEHIQEGIVTHTFCGTIEYMAPEILTRSGHGKAVD 261
            ||||||.:..:||||||           :.|........:.:|.||.||::||:|..|......|
Yeast   307 ENILLDGEMKIKLTDFGTAKLLNPTNNSVSKPEYDLSTRSKSFVGTAEYVSPELLNDSFTDYRCD 371

  Fly   262 WWSLGALMFDMLTGVPPFTAENRKKTIETILKAKLNLPAYLTPEARDLVRRLMKRQEPQRLGSGP 326
            .|:.|.::|.|:.|.|||.|.|...|.:.::|.:...........||||::::.:...:||
Yeast   372 IWAFGCILFQMIAGKPPFKATNEYLTFQKVMKVQYAFTPGFPLIIRDLVKKILVKNLDRRL---- 432

  Fly   327 EDAAAVQIHPFFKHVNWDDVLARRLEPP-IKPLLRSEDDVSQFDTRFTRQIPVDSPDDTTLSESA 390
             ..:.::.|.|||.:|:.|.......|| |||.        :.:.:..:.:|..| |...:.:|.
Yeast   433 -TISQIKEHHFFKDLNFKDGSVWSKTPPEIKPY--------KINAKSMQAMPSGS-DRKLVKKSV 487

  Fly   391 NLIFQGFTYV-------APSILEDMH--------------------------------------- 409
            |.:  |.:::       :||:.|..|
Yeast   488 NTL--GKSHLVTQRSASSPSVEETTHSTLYNNNTHASTESEISIKKRPTDERTAQILENARKGIN 550

  Fly   410 -RANRMPARSP---------------RRTPRQLPDSSFRLQFPSANVGANAP-LAMHGHSQRSGM 457
             |.|:...|:|               ::|.:..|.||.:....|:....:.| ......|..|..
Yeast   551 NRKNQPGKRTPSGAASAALAASAALTKKTMQSYPTSSSKSSRSSSPATTSRPGTYKRTSSTESKP 615

  Fly   458 FARATP----------PHHMQTFAPRPSP 476
            ||::.|          |  |..:.|..||
Yeast   616 FAKSPPLSASVLSSKVP--MPPYTPPMSP 642

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
S6k	NP_523941.2	STKc_p70S6K	81..402	CDD:270736	102/342 (30%)
PKH2	NP_014541.1	STKc_PDK1	177..443	CDD:270733	89/276 (32%)