DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment S6k and S6K2

DIOPT Version :9

Sequence 1:	NP_001261450.1	Gene:	S6k / 38654	FlyBaseID:	FBgn0283472	Length:	490	Species:	Drosophila melanogaster
Sequence 2:	NP_001327294.1	Gene:	S6K2 / 820019	AraportID:	AT3G08720	Length:	471	Species:	Arabidopsis thaliana

Alignment Length:	395	Identity:	162/395 - (41%)
Similarity:	251/395 - (63%)	Gaps:	26/395 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly    16 HDLELQDDKARDSDD-----DRIELDDVDLEPELCINLHQDTEGQETIQLCEENVNPGKIK--LG 73
            |.|::.....|:::|     :.:|.:.:....|...|  .||:.::         :|.::.  :|
plant    83 HSLKMNKLTLRETEDSVDLVECVEGESIKENDEFSGN--DDTDSEK---------SPEEVSGVVG 136

  Fly    74 PKDFELKKVLGKGGYGKVFQVRKTAGRDANKYFAMKVLKKASIVTNQKDTA-HTRAERNILEAVK 137
            .:|||:.||:|:|.:|||:||||   :|.::.:||||::|..||  :|:.| :.:|||:||..:.
plant   137 IEDFEVLKVVGQGAFGKVYQVRK---KDTSEIYAMKVMRKDKIV--EKNHAEYMKAERDILTKID 196

  Fly   138 HPFIVELVYAFQTDGKLYLILEYLSGGELFMHLEREGIFLEDTTCFYLSEIILALGHLHKLGIIY 202
            |||||:|.|:|||..:|||:|::::||.||..|..:|:|.||....|.:||:.|:.|||:.||::
plant   197 HPFIVQLKYSFQTKYRLYLVLDFINGGHLFFQLYHQGLFREDLARVYTAEIVSAVSHLHEKGIMH 261

  Fly   203 RDLKPENILLDAQGHVKLTDFGLCKEHIQEGIVTHTFCGTIEYMAPEILTRSGHGKAVDWWSLGA 267
            |||||||||:|..|||.||||||.|| .:|...:::.|||.|||||||:...||.||.||||:|.
plant   262 RDLKPENILMDVDGHVMLTDFGLAKE-FEENTRSNSMCGTTEYMAPEIVRGKGHDKAADWWSVGI 325

  Fly   268 LMFDMLTGVPPFTAENRKKTIETILKAKLNLPAYLTPEARDLVRRLMKRQEPQRLGSGPEDAAAV 332
            |:::||||.|||.. ::.|..:.|:|.|:.||.:|:.||..|::.|::::..:||||||..|..:
plant   326 LLYEMLTGKPPFLG-SKGKIQQKIVKDKIKLPQFLSNEAHALLKGLLQKEPERRLGSGPSGAEEI 389

  Fly   333 QIHPFFKHVNWDDVLARRLEPPIKPLLRSEDDVSQFDTRFTRQIPVDSPDDTTLSESANLIFQGF 397
            :.|.:||.:||..:.||.::|..||.:.....::.||..:|....:|||..:..|::....|..|
plant   390 KKHKWFKAINWKKLEAREVQPSFKPAVSGRQCIANFDKCWTDMSVLDSPASSPNSDAKANPFTNF 454

  Fly   398 TYVAP 402
            |||.|
plant   455 TYVRP 459

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
S6k	NP_001261450.1	PTZ00263	76..397	CDD:140289	146/321 (45%)
S6k	NP_001261450.1	STKc_p70S6K	81..402	CDD:270736	147/321 (46%)
S6K2	NP_001327294.1	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	259	1.000	Domainoid score	I491
eggNOG	1	0.900	-	-		E1_KOG0598
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H81703
Inparanoid	1	1.050	302	1.000	Inparanoid score	I779
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1132245at2759
OrthoFinder	1	1.000	-	-		FOG0001793
OrthoInspector	1	1.000	-	-		mtm1096
orthoMCL	1	0.900	-	-		OOG6_100157
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X1494
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	10	9.770