Protein Alignment S6k and SGK1

DIOPT Version :10

• Sequence 1: NP_523941.2
• Gene: S6k / 38654
• FlyBaseID: FBgn0283472
• Length: 490
• Species: Drosophila melanogaster
• Sequence 2: NP_001137148.1
• Gene: SGK1 / 6446
• HGNCID: 10810
• Length: 526
• Species: Homo sapiens
• Alignment Length: 387
• Identity: 164/387 - (42%)
• Similarity: 230/387 - (59%)
• Gaps: 48/387 - (12%)

  Fly    41 EPELCINLHQDTEGQETIQLCEENVNPG-------KIKLG--------PKDFELKKVLGKGGYGK 90
            ||||.                  |.||.       :|.||        |.||...||:|||.:||
Human   160 EPELM------------------NANPSPPPSPSQQINLGPSSNPHAKPSDFHFLKVIGKGSFGK 206

  Fly    91 VFQVRKTAGRDANKYFAMKVLKKASIVTNQKDTAHTRAERNI-LEAVKHPFIVELVYAFQTDGKL 154
            |...|..|   ...::|:|||:|.:|: .:|:..|..:|||: |:.|||||:|.|.::|||..||
Human   207 VLLARHKA---EEVFYAVKVLQKKAIL-KKKEEKHIMSERNVLLKNVKHPFLVGLHFSFQTADKL 267

  Fly   155 YLILEYLSGGELFMHLEREGIFLEDTTCFYLSEIILALGHLHKLGIIYRDLKPENILLDAQGHVK 219
            |.:|:|::|||||.||:||..|||....||.:||..|||:||.|.|:||||||||||||:|||:.
Human   268 YFVLDYINGGELFYHLQRERCFLEPRARFYAAEIASALGYLHSLNIVYRDLKPENILLDSQGHIV 332

  Fly   220 LTDFGLCKEHIQEGIVTHTFCGTIEYMAPEILTRSGHGKAVDWWSLGALMFDMLTGVPPFTAENR 284
            |||||||||:|:....|.|||||.||:|||:|.:..:.:.||||.|||::::||.|:|||.:.|.
Human   333 LTDFGLCKENIEHNSTTSTFCGTPEYLAPEVLHKQPYDRTVDWWCLGAVLYEMLYGLPPFYSRNT 397

  Fly   285 KKTIETILKAKLNLPAYLTPEARDLVRRLMKRQEPQRLGSGPEDAAAVQIHPFFKHVNWDDVLAR 349
            .:..:.||...|.|...:|..||.|:..|:::...:|||: .:|...::.|.||..:||||::.:
Human   398 AEMYDNILNKPLQLKPNITNSARHLLEGLLQKDRTKRLGA-KDDFMEIKSHVFFSLINWDDLINK 461

  Fly   350 RLEPPIKPLLRSEDDVSQFDTRFTRQIPV-----DSPDDTTLSES---ANLIFQGFTYVAPS 403
            ::.||..|.:...:|:..||..||.: ||     .|||...::.|   |...|.||:|..|:
Human   462 KITPPFNPNVSGPNDLRHFDPEFTEE-PVPNSIGKSPDSVLVTASVKEAAEAFLGFSYAPPT 522

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
S6k	NP_523941.2	STKc_p70S6K	81..402	CDD:270736	150/329 (46%)
SGK1	NP_001137148.1	STKc_SGK	197..519	CDD:270727	149/327 (46%)