DRSC/TRiP Functional Genomics Resources

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Protein Alignment S6k and RPS6KB2

DIOPT Version :9

Sequence 1:NP_001261450.1 Gene:S6k / 38654 FlyBaseID:FBgn0283472 Length:490 Species:Drosophila melanogaster
Sequence 2:NP_003943.2 Gene:RPS6KB2 / 6199 HGNCID:10437 Length:482 Species:Homo sapiens


Alignment Length:472 Identity:291/472 - (61%)
Similarity:341/472 - (72%) Gaps:28/472 - (5%)


- Green bases have known domain annotations that are detailed below.


  Fly    17 DLELQDDKARDSDDDRIELDDVDLEP--ELCINLHQDTEGQETIQLCEENVNPGKIKLGPKDFEL 79
            ||:|:.::..:.:.:. ||...|..|  ||.....:.....|.::|.|.:||.|..::||..|||
Human     6 DLDLETEEGSEGEGEP-ELSPADACPLAELRAAGLEPVGHYEEVELTETSVNVGPERIGPHCFEL 69

  Fly    80 KKVLGKGGYGKVFQVRKTAGRDANKYFAMKVLKKASIVTNQKDTAHTRAERNILEAVKHPFIVEL 144
            .:|||||||||||||||..|.:..|.:|||||:||.||.|.||||||||||||||:|||||||||
Human    70 LRVLGKGGYGKVFQVRKVQGTNLGKIYAMKVLRKAKIVRNAKDTAHTRAERNILESVKHPFIVEL 134

  Fly   145 VYAFQTDGKLYLILEYLSGGELFMHLEREGIFLEDTTCFYLSEIILALGHLHKLGIIYRDLKPEN 209
            .|||||.||||||||.|||||||.||||||||||||.||||:||.|||||||..|||||||||||
Human   135 AYAFQTGGKLYLILECLSGGELFTHLEREGIFLEDTACFYLAEITLALGHLHSQGIIYRDLKPEN 199

  Fly   210 ILLDAQGHVKLTDFGLCKEHIQEGIVTHTFCGTIEYMAPEILTRSGHGKAVDWWSLGALMFDMLT 274
            |:|.:|||:||||||||||.|.||.|||||||||||||||||.||||.:|||||||||||:||||
Human   200 IMLSSQGHIKLTDFGLCKESIHEGAVTHTFCGTIEYMAPEILVRSGHNRAVDWWSLGALMYDMLT 264

  Fly   275 GVPPFTAENRKKTIETILKAKLNLPAYLTPEARDLVRRLMKRQEPQRLGSGPEDAAAVQIHPFFK 339
            |.|||||||||||::.|::.||.||.||||:|||||::.:||...||:|.||.|||.||.||||:
Human   265 GSPPFTAENRKKTMDKIIRGKLALPPYLTPDARDLVKKFLKRNPSQRIGGGPGDAADVQRHPFFR 329

  Fly   340 HVNWDDVLARRLEPPIKPLLRSEDDVSQFDTRFTRQIPVDSPDDTTLSESANLIFQGFTYVAPSI 404
            |:||||:||.|::||.:|.|:||:||||||||||||.||||||||.||||||..|.||||||||:
Human   330 HMNWDDLLAWRVDPPFRPCLQSEEDVSQFDTRFTRQTPVDSPDDTALSESANQAFLGFTYVAPSV 394

  Fly   405 LEDMHR--ANRMPARSPRR---TPRQ-------LPDSSFRLQFPSANVGANAPLAMHGHSQRSGM 457
            |:.:..  :.:...|||||   :||.       .|...||   ||.::.....|.:         
Human   395 LDSIKEGFSFQPKLRSPRRLNSSPRAPVSPLKFSPFEGFR---PSPSLPEPTELPL--------- 447

  Fly   458 FARATPPHHMQTFAPRP 474
             ....||....|.||.|
Human   448 -PPLLPPPPPSTTAPLP 463

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
S6kNP_001261450.1 PTZ00263 76..397 CDD:140289 246/320 (77%)
STKc_p70S6K 81..402 CDD:270736 248/320 (78%)
RPS6KB2NP_003943.2 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..26 5/20 (25%)
S_TKc 67..328 CDD:214567 203/260 (78%)
STKc_p70S6K 70..392 CDD:270736 248/321 (77%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 407..482 19/70 (27%)
Nuclear localization signal. /evidence=ECO:0000269|PubMed:12529391 471..477
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C165140573
Domainoid 1 1.000 427 1.000 Domainoid score I602
eggNOG 1 0.900 - - E1_KOG0598
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 554 1.000 Inparanoid score I1118
Isobase 1 0.950 - 0 Normalized mean entropy S756
OMA 1 1.010 - - QHG51952
OrthoDB 1 1.010 - - D1132245at2759
OrthoFinder 1 1.000 - - FOG0001793
OrthoInspector 1 1.000 - - otm42068
orthoMCL 1 0.900 - - OOG6_100157
Panther 1 1.100 - - O PTHR24351
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R469
SonicParanoid 1 1.000 - - X1494
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
User_Submission 00.000 Not matched by this tool.
1615.750

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