DRSC/TRiP Functional Genomics Resources

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Protein Alignment S6k and RPS6KB1

DIOPT Version :9

Sequence 1:NP_001261450.1 Gene:S6k / 38654 FlyBaseID:FBgn0283472 Length:490 Species:Drosophila melanogaster
Sequence 2:NP_003152.1 Gene:RPS6KB1 / 6198 HGNCID:10436 Length:525 Species:Homo sapiens


Alignment Length:522 Identity:295/522 - (56%)
Similarity:358/522 - (68%) Gaps:75/522 - (14%)


- Green bases have known domain annotations that are detailed below.


  Fly     3 DVSDPSELFDLELHDLELQDDKARDSDDDRIELDD---------VDLEPELCINLHQDTEGQETI 58
            :..|.:.:||::|...|  |..:.|..::..:|::         .:|..|.|          |..
Human    20 EAEDMAGVFDIDLDQPE--DAGSEDELEEGGQLNESMDHGGVGPYELGMEHC----------EKF 72

  Fly    59 QLCEENVNPGKIKLGPKDFELKKVLGKGGYGKVFQVRKTAGRDANKYFAMKVLKKASIVTNQKDT 123
            ::.|.:||.|..|:.|:.|||.:|||||||||||||||..|.:..|.|||||||||.||.|.|||
Human    73 EISETSVNRGPEKIRPECFELLRVLGKGGYGKVFQVRKVTGANTGKIFAMKVLKKAMIVRNAKDT 137

  Fly   124 AHTRAERNILEAVKHPFIVELVYAFQTDGKLYLILEYLSGGELFMHLEREGIFLEDTTCFYLSEI 188
            |||:|||||||.|||||||:|:|||||.|||||||||||||||||.|||||||:|||.||||:||
Human   138 AHTKAERNILEEVKHPFIVDLIYAFQTGGKLYLILEYLSGGELFMQLEREGIFMEDTACFYLAEI 202

  Fly   189 ILALGHLHKLGIIYRDLKPENILLDAQGHVKLTDFGLCKEHIQEGIVTHTFCGTIEYMAPEILTR 253
            .:||||||:.||||||||||||:|:.||||||||||||||.|.:|.|||||||||||||||||.|
Human   203 SMALGHLHQKGIIYRDLKPENIMLNHQGHVKLTDFGLCKESIHDGTVTHTFCGTIEYMAPEILMR 267

  Fly   254 SGHGKAVDWWSLGALMFDMLTGVPPFTAENRKKTIETILKAKLNLPAYLTPEARDLVRRLMKRQE 318
            |||.:|||||||||||:|||||.||||.|||||||:.|||.|||||.|||.|||||:::|:||..
Human   268 SGHNRAVDWWSLGALMYDMLTGAPPFTGENRKKTIDKILKCKLNLPPYLTQEARDLLKKLLKRNA 332

  Fly   319 PQRLGSGPEDAAAVQIHPFFKHVNWDDVLARRLEPPIKPLLRSEDDVSQFDTRFTRQIPVDSPDD 383
            ..|||:||.||..||.||||:|:||:::|||::|||.||||:||:||||||::||||.|||||||
Human   333 ASRLGAGPGDAGEVQAHPFFRHINWEELLARKVEPPFKPLLQSEEDVSQFDSKFTRQTPVDSPDD 397

  Fly   384 TTLSESANLIFQGFTYVAPSILEDMHR--ANRMPARSPRR---TPR------------------- 424
            :|||||||.:|.||||||||:||.:..  :.....|||||   :||                   
Human   398 STLSESANQVFLGFTYVAPSVLESVKEKFSFEPKIRSPRRFIGSPRTPVSPVKFSPGDFWGRGAS 462

  Fly   425 ------QLPDSSFRLQFPSANVG-----------ANAPLAMHGHSQRSGMFAR-ATP-----PHH 466
                  |.|     :::|....|           |:|||.:  ....||.:.: |.|     |.|
Human   463 ASTANPQTP-----VEYPMETSGIEQMDVTMSGEASAPLPI--RQPNSGPYKKQAFPMISKRPEH 520

  Fly   467 MQ 468
            ::
Human   521 LR 522

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
S6kNP_001261450.1 PTZ00263 76..397 CDD:140289 246/320 (77%)
STKc_p70S6K 81..402 CDD:270736 248/320 (78%)
RPS6KB1NP_003152.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..54 8/35 (23%)
TOS motif 28..32 2/3 (67%)
STKc_p70S6K 94..416 CDD:270736 248/321 (77%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 380..399 15/18 (83%)
Autoinhibitory domain 424..525 21/106 (20%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C165140569
Domainoid 1 1.000 427 1.000 Domainoid score I602
eggNOG 1 0.900 - - E1_KOG0598
Hieranoid 1 1.000 - -
Homologene 1 1.000 - - H81703
Inparanoid 1 1.050 554 1.000 Inparanoid score I1118
Isobase 00.000 Not matched by this tool.
OMA 1 1.010 - - QHG51952
OrthoDB 1 1.010 - - D1132245at2759
OrthoFinder 1 1.000 - - FOG0001793
OrthoInspector 1 1.000 - - otm42068
orthoMCL 1 0.900 - - OOG6_100157
Panther 1 1.100 - - LDO PTHR24351
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 1 1.000 - - X1494
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
User_Submission 00.000 Not matched by this tool.
1514.770

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