DRSC/TRiP Functional Genomics Resources

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Protein Alignment S6k and Rps6kb2

DIOPT Version :9

Sequence 1:NP_001261450.1 Gene:S6k / 38654 FlyBaseID:FBgn0283472 Length:490 Species:Drosophila melanogaster
Sequence 2:NP_067460.1 Gene:Rps6kb2 / 58988 MGIID:1927343 Length:485 Species:Mus musculus


Alignment Length:485 Identity:288/485 - (59%)
Similarity:338/485 - (69%) Gaps:26/485 - (5%)


- Green bases have known domain annotations that are detailed below.


  Fly    10 LFDLELHDLELQDDKARDSDDDRIELDDVDLEPELCINLHQDTEGQ-ETIQLCEENVNPGKIKLG 73
            :|||   |||.::....:.:.:....|...|.......|  :|.|. |.::|.|.:||.|..::|
Mouse     4 VFDL---DLETEEGSEGEGEPEFSPADVCPLGELRAAGL--ETVGHYEEVELTESSVNLGPERIG 63

  Fly    74 PKDFELKKVLGKGGYGKVFQVRKTAGRDANKYFAMKVLKKASIVTNQKDTAHTRAERNILEAVKH 138
            |..|||..|||||||||||||||..|.:..|.:|||||:||.||.:.||||||||||||||:|||
Mouse    64 PHCFELLSVLGKGGYGKVFQVRKVQGTNLGKIYAMKVLRKAKIVCSAKDTAHTRAERNILESVKH 128

  Fly   139 PFIVELVYAFQTDGKLYLILEYLSGGELFMHLEREGIFLEDTTCFYLSEIILALGHLHKLGIIYR 203
            ||||||.|||||.||||||||.|||||||.||||||||||||.||||:||.|||||||..|||||
Mouse   129 PFIVELAYAFQTGGKLYLILECLSGGELFTHLEREGIFLEDTACFYLAEITLALGHLHSHGIIYR 193

  Fly   204 DLKPENILLDAQGHVKLTDFGLCKEHIQEGIVTHTFCGTIEYMAPEILTRSGHGKAVDWWSLGAL 268
            |||||||:|.:|||:||||||||||.|.||.:||||||||||||||||.|:||.:||||||||||
Mouse   194 DLKPENIMLSSQGHIKLTDFGLCKESIHEGAITHTFCGTIEYMAPEILVRTGHNRAVDWWSLGAL 258

  Fly   269 MFDMLTGVPPFTAENRKKTIETILKAKLNLPAYLTPEARDLVRRLMKRQEPQRLGSGPEDAAAVQ 333
            |:|||||.|||||||||||::.|:|.||.||.||||:||||.::.:||...||:|.|..|||.||
Mouse   259 MYDMLTGSPPFTAENRKKTMDKIIKGKLVLPPYLTPDARDLAKKFLKRNPTQRIGGGLGDAADVQ 323

  Fly   334 IHPFFKHVNWDDVLARRLEPPIKPLLRSEDDVSQFDTRFTRQIPVDSPDDTTLSESANLIFQGFT 398
            .||||:|:||||:||||::||.:|.|:||:||||||.|||||.||||||||.||||||..|.|||
Mouse   324 RHPFFRHINWDDLLARRVDPPFRPSLQSEEDVSQFDARFTRQTPVDSPDDTALSESANQAFLGFT 388

  Fly   399 YVAPSILEDMHR--ANRMPARSPRRTPRQLPDSSFRLQFPSANVGANAPLAMHGHSQRSGMFARA 461
            |||||:|:.:..  :.:...|||||                .|.....|::....|...|.....
Mouse   389 YVAPSVLDSIKEGFSFQPKLRSPRR----------------LNSSPRTPISPLKFSPFEGFRPSP 437

  Fly   462 TPPHHMQTFAP--RPSPAQDEMMDVQGLPM 489
            .||..|:...|  .|||..........||:
Mouse   438 GPPEPMEPSLPPLLPSPPSPPPTSTAPLPI 467

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
S6kNP_001261450.1 PTZ00263 76..397 CDD:140289 242/320 (76%)
STKc_p70S6K 81..402 CDD:270736 244/320 (76%)
Rps6kb2NP_067460.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..26 6/24 (25%)
S_TKc 67..328 CDD:214567 199/260 (77%)
STKc_p70S6K 70..392 CDD:270736 244/321 (76%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 407..485 18/77 (23%)
Nuclear localization signal. /evidence=ECO:0000250 474..480
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C167830550
Domainoid 1 1.000 427 1.000 Domainoid score I604
eggNOG 1 0.900 - - E1_KOG0598
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 554 1.000 Inparanoid score I1112
Isobase 1 0.950 - 0 Normalized mean entropy S756
OMA 1 1.010 - - QHG51952
OrthoDB 1 1.010 - - D1132245at2759
OrthoFinder 1 1.000 - - FOG0001793
OrthoInspector 1 1.000 - - otm44122
orthoMCL 1 0.900 - - OOG6_100157
Panther 1 1.100 - - O PTHR24351
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R469
SonicParanoid 1 1.000 - - X1494
SwiftOrtho 1 1.000 - -
TreeFam 1 0.960 - -
1716.750

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