DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment S6k and rps6ka2

DIOPT Version :9

Sequence 1:	NP_001261450.1	Gene:	S6k / 38654	FlyBaseID:	FBgn0283472	Length:	490	Species:	Drosophila melanogaster
Sequence 2:	XP_699952.2	Gene:	rps6ka2 / 571285	ZFINID:	ZDB-GENE-090827-1	Length:	733	Species:	Danio rerio

Alignment Length:	381	Identity:	183/381 - (48%)
Similarity:	247/381 - (64%)	Gaps:	18/381 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly    24 KARDSDDDRIELDDVDLEPELCINLHQDTEGQETIQLCEENVNPGKIKLGPKDFELKKVLGKGGY 88
            |:|.......:|:|..:..|..|:.|               |..|..|..|..|||.||||:|.|
Zfish    21 KSRSKSSSLCKLEDDSILKEFDISHH---------------VKEGFEKADPSQFELLKVLGQGSY 70

  Fly    89 GKVFQVRKTAGRDANKYFAMKVLKKASIVTNQKDTAHTRAERNILEAVKHPFIVELVYAFQTDGK 153
            ||||.|||..|.|..:.:||||||||::  ..:|...::.||:||..|.|||||:|.|||||:||
Zfish    71 GKVFLVRKIKGSDTGQLYAMKVLKKATL--KVRDRVRSKMERDILAEVNHPFIVKLHYAFQTEGK 133

  Fly   154 LYLILEYLSGGELFMHLEREGIFLEDTTCFYLSEIILALGHLHKLGIIYRDLKPENILLDAQGHV 218
            |||||::|.||:||..|.:|.:|.|:...|||:|:.|||.|||.||||||||||||||||.:||:
Zfish   134 LYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHI 198

  Fly   219 KLTDFGLCKEHIQEGIVTHTFCGTIEYMAPEILTRSGHGKAVDWWSLGALMFDMLTGVPPFTAEN 283
            |:|||||.||.|......::|||||||||||::.|.||.::.||||.|.|||:||||..||..::
Zfish   199 KITDFGLSKEAIDHDKRAYSFCGTIEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGSLPFQGKD 263

  Fly   284 RKKTIETILKAKLNLPAYLTPEARDLVRRLMKRQEPQRLGSGPEDAAAVQIHPFFKHVNWDDVLA 348
            ||:|:..||||||.:|.:|:||.:.|:|.|.||....|||:||:....::.|.||..::|:.:..
Zfish   264 RKETMALILKAKLGMPQFLSPEVQSLLRALFKRNPSNRLGAGPDGVEEIKRHIFFATIDWNKLYR 328

  Fly   349 RRLEPPIKPLLRSEDDVSQFDTRFTRQIPVDSPDDTTLSESANLIFQGFTYVAPSI 404
            |.::||.||.:...:|...||..||.:.|.||| ....|.:|:.:|:||::||.::
Zfish   329 REIKPPFKPAVGRPEDTFHFDPEFTSRTPTDSP-GVPASANAHQLFRGFSFVATNL 383

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
S6k	NP_001261450.1	PTZ00263	76..397	CDD:140289	168/320 (53%)
S6k	NP_001261450.1	STKc_p70S6K	81..402	CDD:270736	168/320 (53%)
rps6ka2	XP_699952.2	S_TKc	59..318	CDD:214567	148/260 (57%)
		STKc_RSK_N	63..379	CDD:270734	167/318 (53%)
		PKc_like	411..703	CDD:304357
		Pkinase	415..672	CDD:278497
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170573236
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1132245at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R469
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	5	4.880