DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment S6k and rps6ka5

DIOPT Version :9

Sequence 1:	NP_001261450.1	Gene:	S6k / 38654	FlyBaseID:	FBgn0283472	Length:	490	Species:	Drosophila melanogaster
Sequence 2:	XP_693550.4	Gene:	rps6ka5 / 565173	ZFINID:	ZDB-GENE-130530-693	Length:	802	Species:	Danio rerio

Alignment Length:	382	Identity:	184/382 - (48%)
Similarity:	244/382 - (63%)	Gaps:	20/382 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly    71 KLGPKDFELKKVLGKGGYGKVFQVRKTAGRDANKYFAMKVLKKASIVTNQKDTAHTRAERNILEA 135
            ::|.::|||.||||.|.|||||.|||.:|.|:.|.:||||||||:||...|...|||.||.:||.
Zfish    32 RVGIENFELLKVLGTGAYGKVFLVRKVSGHDSGKLYAMKVLKKATIVQKAKTAEHTRTERQVLEH 96

  Fly   136 VKH-PFIVELVYAFQTDGKLYLILEYLSGGELFMHLEREGIFLEDTTCFYLSEIILALGHLHKLG 199
            ::. ||:|.|.||||||.||:|||:|::|||||.||.:...|.|.....|..||:|||.||||||
Zfish    97 IRQSPFLVTLHYAFQTDTKLHLILDYVNGGELFTHLVQRVRFKEQEVTLYSGEIVLALEHLHKLG 161

  Fly   200 IIYRDLKPENILLDAQGHVKLTDFGLCKEHIQEGIVTHTFCGTIEYMAPEILT--RSGHGKAVDW 262
            |:|||||.||||||:.||:.||||||.|| ..|....::.|||||||||||:.  ..||.|||||
Zfish   162 IVYRDLKLENILLDSNGHIVLTDFGLSKE-FHEVERAYSICGTIEYMAPEIVAGGEGGHDKAVDW 225

  Fly   263 WSLGALMFDMLTGVPPFTA---ENRKKTI-ETILKAKLNLPAYLTPEARDLVRRLMKRQEPQRLG 323
            ||:|.||:::|||..|||.   ||....| |.|:|.....|..:.|.|:|:::||:.:...:|||
Zfish   226 WSMGVLMYELLTGGSPFTVDGDENSHSDIAERIMKKDPPFPKDMGPLAKDIIQRLLIKDPKKRLG 290

  Fly   324 SGPEDAAAVQIHPFFKHVNWDDVLARRLEPPIKPLLRSEDDVSQFDTRFTRQIPVDSPDDTTLSE 388
            |||..|..|:.|||::.:||:|:.|:::..|.||::|.|.|||.|...||...|..||  ..|..
Zfish   291 SGPSGAQNVKKHPFYQKLNWEDLAAKKVRAPFKPVIRDELDVSNFAEEFTEMDPTYSP--AALPN 353

  Fly   389 SANLIFQGFTYVAPSILEDMHRANRMPARSPRRTPR----------QLPDSSFRLQF 435
            :.:.||||::::|||||...:.....||:....:.|          .:.||.|.:.:
Zfish   354 NCDRIFQGYSFMAPSILFKRNAVMDDPAQLCGGSERPGSAAVARSAMMKDSPFYMNY 410

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
S6k	NP_001261450.1	PTZ00263	76..397	CDD:140289	171/327 (52%)
S6k	NP_001261450.1	STKc_p70S6K	81..402	CDD:270736	169/327 (52%)
rps6ka5	XP_693550.4	PKc_like	37..367	CDD:304357	172/332 (52%)
		S_TKc	38..304	CDD:214567	147/266 (55%)
		PKc_like	405..714	CDD:304357	1/6 (17%)
		S_TKc	419..663	CDD:214567
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170573234
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1132245at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R469
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	3.880