DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment S6k and STK32B

DIOPT Version :9

Sequence 1:	NP_001261450.1	Gene:	S6k / 38654	FlyBaseID:	FBgn0283472	Length:	490	Species:	Drosophila melanogaster
Sequence 2:	NP_060871.1	Gene:	STK32B / 55351	HGNCID:	14217	Length:	414	Species:	Homo sapiens

Alignment Length:	289	Identity:	96/289 - (33%)
Similarity:	156/289 - (53%)	Gaps:	17/289 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly    77 FELKKVLGKGGYGKVFQVRKTAGRDANKYFAMKVLKKASIVTNQKDTAHTRAERNILEAVKHPFI 141
            |::.:.:|||.:|||..|:|   ||..|.:|||.:.|...: .:.:..:...|..|::.::|||:
Human    23 FQILRAIGKGSFGKVCIVQK---RDTKKMYAMKYMNKQKCI-ERDEVRNVFRELQIMQGLEHPFL 83

  Fly   142 VELVYAFQTDGKLYLILEYLSGGELFMHLEREGIFLEDTTCFYLSEIILALGHLHKLGIIYRDLK 206
            |.|.|:||.:..::::::.|.||:|..||::...|.|.|...|:.|:.|||.:|.:..||:||:|
Human    84 VNLWYSFQDEEDMFMVVDLLLGGDLRYHLQQNVHFTEGTVKLYICELALALEYLQRYHIIHRDIK 148

  Fly   207 PENILLDAQGHVKLTDFGLCKEHIQEGIV-THTFCGTIEYMAPEI----LTRS-GHGKAVDWWSL 265
            |:|||||..|||.:|||.:..  :.:|.. ..:..||..|||||:    :.|. |:...||||||
Human   149 PDNILLDEHGHVHITDFNIAT--VVKGAERASSMAGTKPYMAPEVFQVYMDRGPGYSYPVDWWSL 211

  Fly   266 GALMFDMLTGVPPFTAENRKKTIETILKAKLNLPAYLTPEARDLVRRLMK--RQEPQRLGSGPED 328
            |...:::|.|..|:...:.....|.:...|:....|.:...:.:|..|.|  .::|:...|...|
Human   212 GITAYELLRGWRPYEIHSVTPIDEILNMFKVERVHYSSTWCKGMVALLRKLLTKDPESRVSSLHD 276

  Fly   329 AAAVQIHPFFKHVNWDDVLARRLEPPIKP 357
               :|..|:...:|||.|..:.|.|...|
Human   277 ---IQSVPYLADMNWDAVFKKALMPGFVP 302

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
S6k	NP_001261450.1	PTZ00263	76..397	CDD:140289	96/289 (33%)
S6k	NP_001261450.1	STKc_p70S6K	81..402	CDD:270736	95/285 (33%)
STK32B	NP_060871.1	STKc_Yank1	22..283	CDD:270730	89/268 (33%)
		S_TKc	23..270	CDD:214567	85/252 (34%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	374..396
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0598
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900