DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment S6k and Akt1

DIOPT Version :9

Sequence 1:	NP_001261450.1	Gene:	S6k / 38654	FlyBaseID:	FBgn0283472	Length:	490	Species:	Drosophila melanogaster
Sequence 2:	NP_732113.3	Gene:	Akt1 / 41957	FlyBaseID:	FBgn0010379	Length:	611	Species:	Drosophila melanogaster

Alignment Length:	381	Identity:	159/381 - (41%)
Similarity:	230/381 - (60%)	Gaps:	30/381 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly    31 DRIELDDVDL----EPELCINLHQDTEGQETIQ--LCEENVNPGKIKLGPKDFELKKVLGKGGYG 89
            ::.::.|||:    |.||        ..|.::|  .|..:   |..|:..::||..||||||.:|
  Fly   225 EQTDMTDVDMATIAEDEL--------SEQFSVQGTTCNSS---GVKKVTLENFEFLKVLGKGTFG 278

  Fly    90 KVFQVRKTAGRDANKYFAMKVLKKASIVTNQKD-TAHTRAERNILEAVKHPFIVELVYAFQTDGK 153
            ||...|:.|   ..|.:|:|:|||..|:  ||| .|||..|..:|::..|||::.|.|:|||:.:
  Fly   279 KVILCREKA---TAKLYAIKILKKEVII--QKDEVAHTLTESRVLKSTNHPFLISLKYSFQTNDR 338

  Fly   154 LYLILEYLSGGELFMHLEREGIFLEDTTCFYLSEIILALGHLHKLGIIYRDLKPENILLDAQGHV 218
            |..:::|::|||||.||..|.||.||.|.||.:|||.|||:||..||||||||.||:|||..||:
  Fly   339 LCFVMQYVNGGELFWHLSHERIFTEDRTRFYGAEIISALGYLHSQGIIYRDLKLENLLLDKDGHI 403

  Fly   219 KLTDFGLCKEHIQEGIVTHTFCGTIEYMAPEILTRSGHGKAVDWWSLGALMFDMLTGVPPFTAEN 283
            |:.|||||||.|..|..|.|||||.||:|||:|..:.:|:|||||..|.:|::|:.|..||...:
  Fly   404 KVADFGLCKEDITYGRTTKTFCGTPEYLAPEVLDDNDYGQAVDWWGTGVVMYEMICGRLPFYNRD 468

  Fly   284 RKKTIETILKAKLNLPAYLTPEARDLVRRLMKRQEPQRLGSGPEDAAAVQIHPFFKHVNWDDVLA 348
            .......||..::..|..:|.||::|:..|:.:...:|||.|.:|...:|.||||..:||.|::.
  Fly   469 HDVLFTLILVEEVKFPRNITDEAKNLLAGLLAKDPKKRLGGGKDDVKEIQAHPFFASINWTDLVL 533

  Fly   349 RRLEPPIKPLLRSEDDVSQFDTRFT-RQIPVDSPDDT----TLSESANLIFQGFTY 399
            :::.||.||.:.|:.|...||..|| ..:.:..||.|    :::|..  :|..|:|
  Fly   534 KKIPPPFKPQVTSDTDTRYFDKEFTGESVELTPPDPTGPLGSIAEEP--LFPQFSY 587

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
S6k	NP_001261450.1	PTZ00263	76..397	CDD:140289	146/326 (45%)
S6k	NP_001261450.1	STKc_p70S6K	81..402	CDD:270736	146/325 (45%)
Akt1	NP_732113.3	PH_PKB	105..214	CDD:269947
		PH	107..211	CDD:278594
		S_TKc	266..523	CDD:214567	126/261 (48%)
		STKc_PKB	270..590	CDD:270723	146/325 (45%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100157
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R469
SonicParanoid	0	0.000	Not matched by this tool.
	3	2.840