DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment S6k and akt2l

DIOPT Version :9

Sequence 1:	NP_001261450.1	Gene:	S6k / 38654	FlyBaseID:	FBgn0283472	Length:	490	Species:	Drosophila melanogaster
Sequence 2:	XP_021334818.1	Gene:	akt2l / 403146	ZFINID:	ZDB-GENE-040121-5	Length:	625	Species:	Danio rerio

Alignment Length:	393	Identity:	157/393 - (39%)
Similarity:	231/393 - (58%)	Gaps:	29/393 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly    27 DSDDDRIE-----------LDDVDLEPELCINLHQDTEGQETIQLCEENVNPGKIKLGPKDFELK 80
            ||.|:|.|           |...|::..:.|.....::..|.:::|   ::....::...||:..
Zfish    91 DSSDERDEWMRAIQMVANGLQARDVDEPMEIKYSSPSDALEDMEMC---LSKSSSRVTMNDFDYL 152

  Fly    81 KVLGKGGYGKVFQVRKTAGRDANKYFAMKVLKKASIVTNQKDTAHTRAERNILEAVKHPFIVELV 145
            |:||||.:|||..||:.|   :..|:|||:|:|..|:. :.:.|||..|..:|:..:|||:..|.
Zfish   153 KLLGKGTFGKVILVREKA---SGMYYAMKILRKEVIIA-KDEVAHTVTESRVLQNTRHPFLTTLK 213

  Fly   146 YAFQTDGKLYLILEYLSGGELFMHLEREGIFLEDTTCFYLSEIILALGHLHKLGIIYRDLKPENI 210
            |||||..:|..::||.:|||||.||.||.:|.||...||.:||:.||.:.|...::||.||.||:
Zfish   214 YAFQTHDRLCFVMEYANGGELFFHLSRERVFSEDRARFYGAEIVSALDYPHSQNVVYRHLKLENL 278

  Fly   211 LLDAQGHVKLTDFGLCKEHIQEGIVTHTFCGTIEYMAPEILTRSGHGKAVDWWSLGALMFDMLTG 275
            :||..||:|:||||||||.|.:.....|||||.||:|||:|..:.:|:|||||.||.:|::|:.|
Zfish   279 MLDNDGHIKITDFGLCKEGITDEATMRTFCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCG 343

  Fly   276 VPPFTAENRKKTIETILKAKLNLPAYLTPEARDLVRRLMKRQEPQRLGSGPEDAAAVQIHPFFKH 340
            ..||.:::.::..|.|:..::..|..|:..||.|:..|::::..||||.||:||..|.:|.||..
Zfish   344 RLPFYSQDHERLFEQIVMEEIRFPRSLSTHARALLTGLLRKEPKQRLGGGPDDARDVMMHKFFSG 408

  Fly   341 VNWDDVLARRLEPPIKPLLRSEDDVSQFDTRFTRQ-IPVDSPDDTTLSESANLIFQGFTYVAPSI 404
            |.|||||.::|.||.||.:.||.|...||..||.| |.|..||..:..:...          |.:
Zfish   409 VQWDDVLQKKLLPPFKPQVTSETDTRYFDDEFTAQSITVTPPDKLSCQDVEE----------PEV 463

  Fly   405 LED 407
            |||
Zfish   464 LED 466

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
S6k	NP_001261450.1	PTZ00263	76..397	CDD:140289	143/321 (45%)
S6k	NP_001261450.1	STKc_p70S6K	81..402	CDD:270736	141/321 (44%)
akt2l	XP_021334818.1	PH_PKB	4..111	CDD:269947	5/19 (26%)
		PKc_like	153..462	CDD:328722	141/322 (44%)
		PKc_like	<423..551	CDD:328722	18/54 (33%)
		S_TK_X	553..621	CDD:214529
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100157
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.810