DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment S6k and rps6kb1

DIOPT Version :9

Sequence 1:	NP_001261450.1	Gene:	S6k / 38654	FlyBaseID:	FBgn0283472	Length:	490	Species:	Drosophila melanogaster
Sequence 2:	XP_012812128.1	Gene:	rps6kb1 / 394938	XenbaseID:	XB-GENE-482409	Length:	530	Species:	Xenopus tropicalis

Alignment Length:	485	Identity:	295/485 - (60%)
Similarity:	350/485 - (72%)	Gaps:	27/485 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 LFDLELHDLE--LQDDKARDSDDDRIELDDVDLEPELCINLHQDTEGQ---ETIQLCEENVNPGK 69
            :||::|...|  :.||:..|.......:|...|..||..:|...:.|.   |..::.|.:||.|.
Frog    24 VFDIDLDQPEDAISDDELEDGGTLTEFMDHGSLSYELGDDLLVSSSGMEHCEKFEISETSVNRGP 88

  Fly    70 IKLGPKDFELKKVLGKGGYGKVFQVRKTAGRDANKYFAMKVLKKASIVTNQKDTAHTRAERNILE 134
            .|:.|:.|||.:|||||||||||||||..|....|.|||||||||.||.|.||||||:|||||||
Frog    89 EKIRPECFELLRVLGKGGYGKVFQVRKVIGAHTGKIFAMKVLKKAMIVRNAKDTAHTKAERNILE 153

  Fly   135 AVKHPFIVELVYAFQTDGKLYLILEYLSGGELFMHLEREGIFLEDTTCFYLSEIILALGHLHKLG 199
            .|||||||:|:|||||.|||||||||||||||||.|||||||:|||.||||:||.:||||||:.|
Frog   154 EVKHPFIVDLIYAFQTGGKLYLILEYLSGGELFMQLEREGIFMEDTACFYLAEISMALGHLHQKG 218

  Fly   200 IIYRDLKPENILLDAQGHVKLTDFGLCKEHIQEGIVTHTFCGTIEYMAPEILTRSGHGKAVDWWS 264
            |||||||||||:|:.||||||||||||||.|.:|.|||||||||||||||||.||||.:||||||
Frog   219 IIYRDLKPENIMLNHQGHVKLTDFGLCKESIHDGTVTHTFCGTIEYMAPEILMRSGHNRAVDWWS 283

  Fly   265 LGALMFDMLTGVPPFTAENRKKTIETILKAKLNLPAYLTPEARDLVRRLMKRQEPQRLGSGPEDA 329
            |||||:|||||.||||.|||||||:.|||.|||||.|||.|||||:::|:||....|||:|..||
Frog   284 LGALMYDMLTGAPPFTGENRKKTIDKILKCKLNLPPYLTQEARDLLKKLLKRNAASRLGAGAGDA 348

  Fly   330 AAVQIHPFFKHVNWDDVLARRLEPPIKPLLRSEDDVSQFDTRFTRQIPVDSPDDTTLSESANLIF 394
            ..||.||||:|:||:::|||::|||.||||:||:||||||::||||.|||||||.|||||||.:|
Frog   349 IDVQGHPFFRHINWEELLARKVEPPFKPLLQSEEDVSQFDSKFTRQTPVDSPDDATLSESANQVF 413

  Fly   395 QGFTYVAPSILEDMHR--ANRMPARSPRR---TPRQLPDSSFRLQFPSANVGANAPLAMHGHSQR 454
            .||||||||:||.:..  :.....|||||   :|| .|.|.  ::|...::.|....|...::|.
Frog   414 VGFTYVAPSVLESVKEKFSFEPKIRSPRRFIGSPR-TPVSP--VKFSPGDIWARGAAAGTSNTQT 475

  Fly   455 SGMFARATPPHHMQTFAPRPSPAQDEMMDV 484
            .|.|              |...:..|.|||
Frog   476 PGEF--------------RMEASGVEQMDV 491

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
S6k	NP_001261450.1	PTZ00263	76..397	CDD:140289	245/320 (77%)
S6k	NP_001261450.1	STKc_p70S6K	81..402	CDD:270736	247/320 (77%)
rps6kb1	XP_012812128.1	STKc_p70S6K	99..421	CDD:270736	247/321 (77%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	416	1.000	Domainoid score	I658
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H81703
Inparanoid	1	1.050	552	1.000	Inparanoid score	I1108
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1132245at2759
OrthoFinder	1	1.000	-	-		FOG0001793
OrthoInspector	1	1.000	-	-		oto105111
Panther	1	1.100	-	-	LDO	PTHR24351
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1494
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	8	8.160