Protein Alignment S6k and Rps6ka4

DIOPT Version :10

• Sequence 1: NP_523941.2
• Gene: S6k / 38654
• FlyBaseID: FBgn0283472
• Length: 490
• Species: Drosophila melanogaster
• Sequence 2: NP_001101987.2
• Gene: Rps6ka4 / 361715
• RGDID: 1307277
• Length: 773
• Species: Rattus norvegicus
• Alignment Length: 396
• Identity: 191/396 - (48%)
• Similarity: 253/396 - (63%)
• Gaps: 19/396 - (4%)

  Fly    58 IQLCEENVNPGKIKLGPKDFELKKVLGKGGYGKVFQVRKTAGRDANKYFAMKVLKKASIVTNQKD 122
            :|:.|.|:...:.|:..::|.|.||||.|.|||||.|||..|.||.|.:|||||:||::|...|.
  Rat    14 LQITEANLTGHEEKVSVENFALLKVLGTGAYGKVFLVRKAGGHDAGKLYAMKVLRKAALVQRAKT 78

  Fly   123 TAHTRAERNILEAVKH-PFIVELVYAFQTDGKLYLILEYLSGGELFMHLEREGIFLEDTTCFYLS 186
            ..|||.||::||.|:. ||:|.|.||||||.||:|||:|:||||:|.||.:...|.|.....|..
  Rat    79 QEHTRTERSVLELVRQAPFLVTLHYAFQTDAKLHLILDYVSGGEMFTHLYQRQYFKEAEVRVYGG 143

  Fly   187 EIILALGHLHKLGIIYRDLKPENILLDAQGHVKLTDFGLCKEHI-QEGIVTHTFCGTIEYMAPEI 250
            ||:|||.|||||||||||||.||:|||::||:.||||||.||.: :|...|.:||||||||||||
  Rat   144 EIVLALEHLHKLGIIYRDLKLENVLLDSEGHIVLTDFGLSKEFLTEEKERTFSFCGTIEYMAPEI 208

  Fly   251 L-TRSGHGKAVDWWSLGALMFDMLTGVPPFTAENRKKT----IETILKAKLNLPAYLTPEARDLV 310
            : :::||||||||||||.|:|::|||..|||.|..:.|    ...|||.....|..:.|.|:||:
  Rat   209 IRSKAGHGKAVDWWSLGILLFELLTGASPFTLEGERNTQAEVSRRILKCSPPFPPRIGPVAQDLL 273

  Fly   311 RRLMKRQEPQRLGSGPEDAAAVQIHPFFKHVNWDDVLARRLEPPIKPLLRSEDDVSQFDTRFTRQ 375
            :||:.:...:|||:||:.|..|:.|.||:.::|..:.||::..|.:|.:|||.||..|...|||.
  Rat   274 QRLLCKDPKKRLGAGPQGAQEVKSHLFFQGLDWVALAARKIPAPFRPQIRSELDVGNFAEEFTRL 338

  Fly   376 IPVDSPDDTTLSESANLIFQGFTYVAPSILEDMHR-----------ANRMPARSPRRTPRQLPDS 429
            .||.||..:....... ||||:::||||||.|.:.           |...|.|:.......:.||
  Rat   339 EPVYSPAGSPPPGDPR-IFQGYSFVAPSILFDHNNAVMADVLAAPGAGYRPGRAAVARSAMMQDS 402

  Fly   430 SFRLQF 435
            .|..|:
  Rat   403 PFFQQY 408

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
S6k	NP_523941.2	STKc_p70S6K	81..402	CDD:270736	172/327 (53%)
Rps6ka4	NP_001101987.2	STKc_MSK2_N	32..364	CDD:270765	174/332 (52%)
		Protein Kinases, catalytic domain	404..714	CDD:473864	2/5 (40%)