DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment S6k and rps6ka3a

DIOPT Version :9

Sequence 1:	NP_001261450.1	Gene:	S6k / 38654	FlyBaseID:	FBgn0283472	Length:	490	Species:	Drosophila melanogaster
Sequence 2:	XP_005165175.1	Gene:	rps6ka3a / 338219	ZFINID:	ZDB-GENE-030219-119	Length:	733	Species:	Danio rerio

Alignment Length:	428	Identity:	196/428 - (45%)
Similarity:	270/428 - (63%)	Gaps:	40/428 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MADVSDPSELFDLELHDLELQDDKARDSDDDRIELDDVDLEPELCINLHQDTEGQETIQLCEENV 65
            :|..:||.:  .|.:..||.:||..  .:||.:..|:..:: |:.|..|               |
Zfish     3 LAQCADPWQ--KLPMGHLENEDDSM--IEDDSLVHDEGSVK-EISITHH---------------V 47

  Fly    66 NPGKIKLGPKDFELKKVLGKGGYGKVFQVRKTAGRDANKYFAMKVLKKASIVTNQKDTAHTRAER 130
            ..|..|..|:.|||:||||:|.:||||.|:|.:|.||.:.:||||||||::  ..:|...|:.||
Zfish    48 KEGSEKADPRQFELRKVLGQGSFGKVFLVKKISGPDAGQLYAMKVLKKATL--KVRDRVRTKMER 110

  Fly   131 NILEAVKHPFIVELVYAFQTDGKLYLILEYLSGGELFMHLEREGIFLEDTTCFYLSEIILALGHL 195
            :||..|.|||||:|.|||||:|||||||::|.||:||..|.:|.:|.|:...|||:|:.|||.||
Zfish   111 DILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHL 175

  Fly   196 HKLGIIYRDLKPENILLDAQGHVKLTDFGLCKEHIQEGIVTHTFCGTIEYMAPEILTRSGHGKAV 260
            |.||||||||||||||||..||:|||||||.||.|......::||||:||||||::.|.||.::.
Zfish   176 HGLGIIYRDLKPENILLDDDGHIKLTDFGLSKESIDHENKAYSFCGTVEYMAPEVVNRRGHTQSA 240

  Fly   261 DWWSLGALMFDMLTGVPPFTAENRKKTIETILKAKLNLPAYLTPEARDLVRRLMKRQEPQRLGSG 325
            ||||.|.|||:||||..||..::||:|:..||||||.:|.:|:|||:.|:|.|.||....|||:|
Zfish   241 DWWSYGVLMFEMLTGALPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRNLFKRNPGNRLGAG 305

  Fly   326 PEDAAAVQIHPFFKHVNWDDVLARRLEPPIKPLLRSEDDVSQFDTRFTRQIPVDSPDDTTLSESA 390
            |:....::.|.||..::|:.:..:.:.||.||.::..||...||:.||.:.|.||| ....|.:|
Zfish   306 PDGVEGIKRHSFFTRIDWNKLFRKEVPPPFKPAIKKPDDTFYFDSEFTAKTPRDSP-GVPPSANA 369

  Fly   391 NLIFQGFTYVA-----------------PSILEDMHRA 411
            :.:|:||::||                 .|||:..||:
Zfish   370 HQLFRGFSFVATGVEEESQSPIQSNINMSSILQQSHRS 407

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
S6k	NP_001261450.1	PTZ00263	76..397	CDD:140289	169/320 (53%)
S6k	NP_001261450.1	STKc_p70S6K	81..402	CDD:270736	170/337 (50%)
rps6ka3a	XP_005165175.1	S_TKc	59..318	CDD:214567	149/260 (57%)
		STKc_RSK_N	63..379	CDD:270734	168/318 (53%)
		STKc_RSK2_C	395..733	CDD:271078	5/13 (38%)
		Pkinase	415..672	CDD:278497
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170573224
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1132245at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.850