DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment S6k and rps6kal

DIOPT Version :9

Sequence 1:	NP_001261450.1	Gene:	S6k / 38654	FlyBaseID:	FBgn0283472	Length:	490	Species:	Drosophila melanogaster
Sequence 2:	NP_956367.1	Gene:	rps6kal / 337670	ZFINID:	ZDB-GENE-030131-9616	Length:	740	Species:	Danio rerio

Alignment Length:	413	Identity:	194/413 - (46%)
Similarity:	262/413 - (63%)	Gaps:	23/413 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly    32 RIELDDVDLEPELCINLHQ---DTEGQETIQLCEE----------NVNPGKIKLGPKDFELKKVL 83
            ::|:..|..|    :|.||   :...:|:...|:|          :|..|..|..|..|||.|||
Zfish    13 KMEVQSVSSE----VNGHQIMDEPMEEESYTHCDEGAYKEIPITHHVKEGCEKADPSQFELLKVL 73

  Fly    84 GKGGYGKVFQVRKTAGRDANKYFAMKVLKKASIVTNQKDTAHTRAERNILEAVKHPFIVELVYAF 148
            |:|.:||||.|||..|.||.:.:|||||||||:  ..:|...|:.||:||..|.|||||:|.|||
Zfish    74 GQGSFGKVFLVRKLMGPDAGQLYAMKVLKKASL--KVRDRVRTKMERDILVEVNHPFIVKLHYAF 136

  Fly   149 QTDGKLYLILEYLSGGELFMHLEREGIFLEDTTCFYLSEIILALGHLHKLGIIYRDLKPENILLD 213
            ||:|||||||::|.||::|..|.:|.:|.|:...|||:|:.|||.|||.|||:||||||||||||
Zfish   137 QTEGKLYLILDFLRGGDVFTRLSKEVMFTEEDVKFYLAELALALDHLHNLGIVYRDLKPENILLD 201

  Fly   214 AQGHVKLTDFGLCKEHIQEGIVTHTFCGTIEYMAPEILTRSGHGKAVDWWSLGALMFDMLTGVPP 278
            ..||:|||||||.||.:.:....::||||:||||||::.|.||.::.||||||.|||:||||..|
Zfish   202 EAGHIKLTDFGLSKESVDQDKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSLGVLMFEMLTGTLP 266

  Fly   279 FTAENRKKTIETILKAKLNLPAYLTPEARDLVRRLMKRQEPQRLGSGPEDAAAVQIHPFFKHVNW 343
            |..::|.:|:..||||||.:|.:|:.||:.|:|.|.||....|||:||:....::.|.||..::|
Zfish   267 FQGKDRNETMNMILKAKLGMPQFLSLEAQGLLRMLFKRNPSNRLGAGPDGVEEIKRHTFFSTIDW 331

  Fly   344 DDVLARRLEPPIKPLLRSEDDVSQFDTRFTRQIPVDSPDDTTLSESANLIFQGFTYVAPSILEDM 408
            :.:..|.|:||.||.....||...||..||.:.|.||| ....|.:|:.:|:||::|||..||:.
Zfish   332 NKLYRRELQPPFKPASGKPDDTFCFDPEFTAKTPKDSP-GIPPSANAHQLFKGFSFVAPVSLEES 395

  Fly   409 HRA---NRMPARSPRRTPRQLPD 428
            ..|   |.:|......:..|..|
Zfish   396 KSAPLVNILPIVQVHGSSAQFSD 418

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
S6k	NP_001261450.1	PTZ00263	76..397	CDD:140289	169/320 (53%)
S6k	NP_001261450.1	STKc_p70S6K	81..402	CDD:270736	169/320 (53%)
rps6kal	NP_956367.1	S_TKc	67..326	CDD:214567	147/260 (57%)
		STKc_RSK_N	71..387	CDD:270734	168/318 (53%)
		STKc_RSK4_C	415..709	CDD:271079	2/4 (50%)
		S_TKc	420..677	CDD:214567
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170573226
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1132245at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.850