DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment S6k and Rps6ka6

DIOPT Version :9

Sequence 1:	NP_001261450.1	Gene:	S6k / 38654	FlyBaseID:	FBgn0283472	Length:	490	Species:	Drosophila melanogaster
Sequence 2:	NP_001178650.1	Gene:	Rps6ka6 / 317203	RGDID:	1560817	Length:	860	Species:	Rattus norvegicus

Alignment Length:	404	Identity:	186/404 - (46%)
Similarity:	264/404 - (65%)	Gaps:	11/404 - (2%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 SDPSELFDLELHDLELQDDKARDSDDDRIELDDVDL-EPELCINLHQDTEGQETIQLCEENVNPG 68
            |:|..:|.::...:.::..:.::.:|.::..:.:|. ||..|  ..:|...:..|   .::|..|
  Rat   122 SEPQIVFTMKTAAMVIRQHEHKEVNDLKMVDEPMDEGEPVFC--RREDLVKEIPI---TQHVKEG 181

  Fly    69 KIKLGPKDFELKKVLGKGGYGKVFQVRKTAGRDANKYFAMKVLKKASIVTNQKDTAHTRAERNIL 133
            ..|..|..|:|.||||:|.:||||.|||..|.||.:.:|||||:|||:  ..:|...|:.||:||
  Rat   182 YEKADPAQFDLLKVLGQGSFGKVFLVRKKTGPDAGQLYAMKVLRKASL--KVRDRVRTKMERDIL 244

  Fly   134 EAVKHPFIVELVYAFQTDGKLYLILEYLSGGELFMHLEREGIFLEDTTCFYLSEIILALGHLHKL 198
            ..|.|||||:|.|||||:|||||||::|.||::|..|.:|.:|.|:...|||:|:.|||.|||:|
  Rat   245 VEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDVFTRLSKEVLFTEEDVKFYLAELALALDHLHRL 309

  Fly   199 GIIYRDLKPENILLDAQGHVKLTDFGLCKEHIQEGIVTHTFCGTIEYMAPEILTRSGHGKAVDWW 263
            ||:||||||||||||..||:|||||||.||.:.:....::||||:||||||::.|.||.::.|||
  Rat   310 GIVYRDLKPENILLDEIGHIKLTDFGLSKESVDQEKKAYSFCGTVEYMAPEVVNRRGHSQSADWW 374

  Fly   264 SLGALMFDMLTGVPPFTAENRKKTIETILKAKLNLPAYLTPEARDLVRRLMKRQEPQRLGSGPED 328
            |.|.|||:||||..||..::|.:|:..||||||.:|.:|:.||:.|:|.|.||....||||  |.
  Rat   375 SYGVLMFEMLTGTLPFQGKDRNETMNMILKAKLGMPQFLSAEAQSLLRMLFKRNPANRLGS--EG 437

  Fly   329 AAAVQIHPFFKHVNWDDVLARRLEPPIKPLLRSEDDVSQFDTRFTRQIPVDSPDDTTLSESANLI 393
            ...|:.|.||..::|:.:..|.::||.:|.....||...||..||.:.|.||| ....|.:|:.:
  Rat   438 VEEVKRHAFFSSIDWNKLYKREVQPPFRPASGKPDDTFCFDPEFTAKTPKDSP-GLPASANAHQL 501

  Fly   394 FQGFTYVAPSILED 407
            |:||::||.||.|:
  Rat   502 FKGFSFVATSIAEE 515

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
S6k	NP_001261450.1	PTZ00263	76..397	CDD:140289	165/320 (52%)
S6k	NP_001261450.1	STKc_p70S6K	81..402	CDD:270736	166/320 (52%)
Rps6ka6	NP_001178650.1	S_TKc	190..447	CDD:214567	145/260 (56%)
		STKc_RSK_N	194..508	CDD:270734	165/318 (52%)
		STKc_RSK_C	543..829	CDD:270993
		Pkinase	543..800	CDD:278497
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166334253
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1132245at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.850