DRSC/TRiP Functional Genomics Resources

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Protein Alignment S6k and PKN3

DIOPT Version :10

Sequence 1:NP_523941.2 Gene:S6k / 38654 FlyBaseID:FBgn0283472 Length:490 Species:Drosophila melanogaster
Sequence 2:XP_006717143.1 Gene:PKN3 / 29941 HGNCID:17999 Length:896 Species:Homo sapiens


Alignment Length:378 Identity:136/378 - (35%)
Similarity:215/378 - (56%) Gaps:26/378 - (6%)


- Green bases have known domain annotations that are detailed below.


  Fly    48 LHQDTEGQETIQLCEENVNPGKIKLGP-------------KDFELKKVLGKGGYGKVFQVR-KTA 98
            |.|:...:||.:....::.| :.:.||             :||....|||:|.:|||..|: |..
Human   525 LPQEPTSEETPRTKRPHMEP-RTRRGPSPPASPTRKPPRLQDFRCLAVLGRGHFGKVLLVQFKGT 588

  Fly    99 GRDANKYFAMKVLKKASIVTNQKDTAHTRAERNILEAV---KHPFIVELVYAFQTDGKLYLILEY 160
            |    ||:|:|.|||..:: ::.:......|:.|||||   .|||::.|:..|||......:.|:
Human   589 G----KYYAIKALKKQEVL-SRDEIESLYCEKRILEAVGCTGHPFLLSLLACFQTSSHACFVTEF 648

  Fly   161 LSGGELFMHLEREGIFLEDTTCFYLSEIILALGHLHKLGIIYRDLKPENILLDAQGHVKLTDFGL 225
            :.||:|.|.: .|.:|.|....||::.::|.|..||:..|||||||.:|:||||||.:|:.||||
Human   649 VPGGDLMMQI-HEDVFPEPQARFYVACVVLGLQFLHEKKIIYRDLKLDNLLLDAQGFLKIADFGL 712

  Fly   226 CKEHIQEGIVTHTFCGTIEYMAPEILTRSGHGKAVDWWSLGALMFDMLTGVPPFTAENRKKTIET 290
            |||.|..|..|.|||||.|::|||:||:..:.:|||||.||.|:::||.|..||..:..::..:.
Human   713 CKEGIGFGDRTSTFCGTPEFLAPEVLTQEAYTRAVDWWGLGVLLYEMLVGECPFPGDTEEEVFDC 777

  Fly   291 ILKAKLNLPAYLTPEARDLVRRLMKRQEPQRLGSGPEDAAAVQIHPFFKHVNWDDVLARRLEPPI 355
            |:......|.:|:.:..:.:::|:::...:|||:|.:||..:::.|||:..||..:|||.::||.
Human   778 IVNMDAPYPGFLSVQGLEFIQKLLQKCPEKRLGAGEQDAEEIKVQPFFRTTNWQALLARTIQPPF 842

  Fly   356 KPLLRSEDDVSQFDTRFTRQIPVDSP--DDTTLSESANLIFQGFTYVAPSILE 406
            .|.|....|:..|:..||...|..:|  ..:.|:......|:.|.:|:...||
Human   843 VPTLCGPADLRYFEGEFTGLPPALTPPAPHSLLTARQQAAFRDFDFVSERFLE 895

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
S6kNP_523941.2 STKc_p70S6K 81..402 CDD:270736 125/326 (38%)
PKN3XP_006717143.1 HR1_PKN_1 20..85 CDD:212012
HR1_PKN3_2 104..177 CDD:212022
HR1 177..237 CDD:469609
C2 335..417 CDD:472691
PTZ00449 <485..>561 CDD:185628 7/36 (19%)
STKc_PKN 566..891 CDD:270741 126/330 (38%)
Blue background indicates that the domain is not in the aligned region.

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