DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment S6k and Stk32a

DIOPT Version :9

Sequence 1:	NP_001261450.1	Gene:	S6k / 38654	FlyBaseID:	FBgn0283472	Length:	490	Species:	Drosophila melanogaster
Sequence 2:	NP_848864.1	Gene:	Stk32a / 269019	MGIID:	2442403	Length:	398	Species:	Mus musculus

Alignment Length:	287	Identity:	101/287 - (35%)
Similarity:	162/287 - (56%)	Gaps:	15/287 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly    77 FELKKVLGKGGYGKVFQVRKTAGRDANKYFAMKVLKKASIVTNQKDTAHTRAERNILEAVKHPFI 141
            ||:.:.:|||.:|||..|||   .|..|.:|||.:.|...| .:.:..:...|..|::.::|||:
Mouse    23 FEILRAIGKGSFGKVCIVRK---NDTKKMYAMKYMNKQKCV-ERNEVRNVFKELQIMQGLEHPFL 83

  Fly   142 VELVYAFQTDGKLYLILEYLSGGELFMHLEREGIFLEDTTCFYLSEIILALGHLHKLGIIYRDLK 206
            |.|.|:||.:..::::::.|.||:|..||::...|.|||...::.|:.:||.:|....||:||:|
Mouse    84 VNLWYSFQDEEDMFMVVDLLLGGDLRYHLQQNVHFQEDTVKLFICELAMALDYLQSQRIIHRDMK 148

  Fly   207 PENILLDAQGHVKLTDFGLCKEHIQEGIVTHTFCGTIEYMAPEILT---RSGHGKAVDWWSLGAL 268
            |:|||||..|||.:|||.:.....:|..:| |..||..|||||:.|   .:|:..||||||||..
Mouse   149 PDNILLDEHGHVHITDFNIAAMLPKETRIT-TVAGTKPYMAPEMFTSRKETGYSFAVDWWSLGVT 212

  Fly   269 MFDMLTGVPPF---TAENRKKTIETILKAKLNLPAYLTPEARDLVRRLMKRQEPQRLGSGPEDAA 330
            .:::|.|..|:   ::.:.|:.:.....|.:..|:..:.|...|:::|::....||.    ....
Mouse   213 AYELLRGRRPYHIRSSTSSKEIVNMFETAIVTYPSAWSQEMVSLLKKLLEPNPDQRF----SHLT 273

  Fly   331 AVQIHPFFKHVNWDDVLARRLEPPIKP 357
            .:|..|:...:|||.||.:||.|...|
Mouse   274 DIQNFPYMSDMNWDAVLQKRLIPGFIP 300

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
S6k	NP_001261450.1	PTZ00263	76..397	CDD:140289	101/287 (35%)
S6k	NP_001261450.1	STKc_p70S6K	81..402	CDD:270736	99/283 (35%)
Stk32a	NP_848864.1	STKc_Yank1	22..281	CDD:270730	92/266 (35%)
		S_TKc	23..270	CDD:214567	90/255 (35%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	379..398
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0598
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900