DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment S6k and sck1

DIOPT Version :9

Sequence 1:	NP_001261450.1	Gene:	S6k / 38654	FlyBaseID:	FBgn0283472	Length:	490	Species:	Drosophila melanogaster
Sequence 2:	NP_593754.1	Gene:	sck1 / 2542492	PomBaseID:	SPAC1B9.02c	Length:	696	Species:	Schizosaccharomyces pombe

Alignment Length:	493	Identity:	184/493 - (37%)
Similarity:	269/493 - (54%)	Gaps:	64/493 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MADVSDP----SELFD---------LELHDLELQDDKARDSDDDRIELDDV-----------DLE 41
            :|||..|    ..:||         :.::| :.:|||...|    :::..:           .||
pombe   212 LADVRCPHWDFETVFDVTKMKSQMVVSVYD-KYEDDKFLGS----VKITPIFLHEYVQEAWYKLE 271

  Fly    42 PELCINLHQDTEGQETIQLCEENVNPGKIKLGPKDFELKKVLGKGGYGKVFQVRKTAGRDANKYF 106
            |   ::|.:..||:..::...|::.  .::.||:||...:::|||.:|:|:.|||   .|.|:.:
pombe   272 P---LDLTKSLEGEIKVETIYEHIE--HVRYGPEDFTALRLIGKGTFGQVYLVRK---NDTNRIY 328

  Fly   107 AMKVLKKASIVTNQKDTAHTRAERNILEAV---KHPFIVELVYAFQTDGKLYLILEYLSGGELFM 168
            |||.:.| .::..:|:..||..|||||...   :.||||.|.::|||...||||.:|:||||||.
pombe   329 AMKKISK-KLIVRKKEVTHTLGERNILVRTSLDESPFIVGLKFSFQTASDLYLITDYMSGGELFW 392

  Fly   169 HLEREGIFLEDTTCFYLSEIILALGHLHKLGIIYRDLKPENILLDAQGHVKLTDFGLCKEHIQEG 233
            ||:.||.|.|....||::|::|||.||||..|||||||||||||||.||:.|.||||.|.::...
pombe   393 HLQHEGRFPEQRAKFYIAELVLALEHLHKHDIIYRDLKPENILLDADGHIALCDFGLSKANLSAN 457

  Fly   234 IVTHTFCGTIEYMAPEILTR-SGHGKAVDWWSLGALMFDMLTGVPPFTAENRKKTIETILKAKLN 297
            ..|:|||||.||:|||:|.. .|:.|.||:||||.|:|:|..|..||.|.:.::....|...|:.
pombe   458 ATTNTFCGTTEYLAPEVLLEDKGYTKQVDFWSLGVLVFEMCCGWSPFYAPDVQQMYRNIAFGKVR 522

  Fly   298 LP-AYLTPEARDLVRRLMKRQEPQRLGSGPEDAAAVQIHPFFKHVNWDDVLARRLEPPIKPLLRS 361
            .| ..|:.|.|..||.|:.|....|||: ..|...::.||||..:|||.:..::::||.||.:::
pombe   523 FPKGVLSSEGRSFVRGLLNRNPNHRLGA-VADTTELKEHPFFADINWDLLSKKKVQPPFKPNVQN 586

  Fly   362 EDDVSQFDTRFT----RQIPVDSPDD-----TTLSESANLIFQGFTYVAPSI--------LEDMH 409
            :.|||.||..||    :.|.:.|..|     |.||.:....|:|||:|..||        |::..
pombe   587 DLDVSNFDKEFTNTNVKNINIVSNVDPANASTPLSNTIQDRFRGFTFVNKSIDEQFQNLGLQENE 651

  Fly   410 RANRMPARSPRRTPRQLPDSSFRLQFPSANVGANAPLA 447
            ..:.:.|   .||......:|.........|.||.|:|
pombe   652 ETDNLHA---CRTTTHSSVNSINSHGNPRTVDANDPVA 686

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
S6k	NP_001261450.1	PTZ00263	76..397	CDD:140289	148/334 (44%)
S6k	NP_001261450.1	STKc_p70S6K	81..402	CDD:270736	150/334 (45%)
sck1	NP_593754.1	C2	139..294	CDD:301316	18/91 (20%)
		S_TKc	302..563	CDD:214567	124/265 (47%)
		STKc_Sck1_like	308..633	CDD:270738	148/329 (45%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0598
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100157
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R469
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.740