DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment S6k and Akt2

DIOPT Version :9

Sequence 1:	NP_001261450.1	Gene:	S6k / 38654	FlyBaseID:	FBgn0283472	Length:	490	Species:	Drosophila melanogaster
Sequence 2:	XP_008757330.1	Gene:	Akt2 / 25233	RGDID:	2082	Length:	496	Species:	Rattus norvegicus

Alignment Length:	399	Identity:	166/399 - (41%)
Similarity:	238/399 - (59%)	Gaps:	27/399 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly    27 DSDDDRIE-LDDVDLEPELCINLHQDTEGQE-------------TIQLCEENVNPGKIKLGPKDF 77
            ||.|:|.| :..:.:   :..:|.|...|::             |.::.|..|:..:.|:...||
  Rat   106 DSPDEREEWIRAIQM---VANSLKQRGPGEDAMDYKCGSPSDSSTSEMMEVAVSKARAKVTMNDF 167

  Fly    78 ELKKVLGKGGYGKVFQVRKTAGRDANKYFAMKVLKKASIVTNQKDTAHTRAERNILEAVKHPFIV 142
            :..|:||||.:|||..||:.|   ..:|:|||:|:|..|:. :.:.|||..|..:|:..:|||:.
  Rat   168 DYLKLLGKGTFGKVILVREKA---TGRYYAMKILRKEVIIA-KDEVAHTVTESRVLQNTRHPFLT 228

  Fly   143 ELVYAFQTDGKLYLILEYLSGGELFMHLEREGIFLEDTTCFYLSEIILALGHLHKLGIIYRDLKP 207
            .|.|||||..:|..::||.:|||||.||.||.:|.||...||.:||:.||.:||...::|||:|.
  Rat   229 ALKYAFQTHDRLCFVMEYANGGELFFHLSRERVFTEDRARFYGAEIVSALEYLHSRDVVYRDIKL 293

  Fly   208 ENILLDAQGHVKLTDFGLCKEHIQEGIVTHTFCGTIEYMAPEILTRSGHGKAVDWWSLGALMFDM 272
            ||::||..||:|:||||||||.|.:|....|||||.||:|||:|..:.:|:|||||.||.:|::|
  Rat   294 ENLMLDKDGHIKITDFGLCKEGISDGATMKTFCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEM 358

  Fly   273 LTGVPPFTAENRKKTIETILKAKLNLPAYLTPEARDLVRRLMKRQEPQRLGSGPEDAAAVQIHPF 337
            :.|..||..::.::..|.||..::..|..|.|||:.|:..|:|:...||||.||.||..|..|.|
  Rat   359 MCGRLPFYNQDHERLFELILMEEIRFPRTLGPEAKSLLAGLLKKDPKQRLGGGPSDAKEVMEHRF 423

  Fly   338 FKHVNWDDVLARRLEPPIKPLLRSEDDVSQFDTRFTRQ-IPVDSPD--DT--TLSESANLIFQGF 397
            |..:||.||:.::|.||.||.:.||.|...||..||.| |.:..||  |:  :|.......|..|
  Rat   424 FLSINWQDVVQKKLLPPFKPQVTSEVDTRYFDDEFTAQSITITPPDRYDSLGSLELDQRTHFPQF 488

  Fly   398 TYVAPSILE 406
            :|.| ||.|
  Rat   489 SYSA-SIRE 496

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
S6k	NP_001261450.1	PTZ00263	76..397	CDD:140289	148/325 (46%)
S6k	NP_001261450.1	STKc_p70S6K	81..402	CDD:270736	148/325 (46%)
Akt2	XP_008757330.1	PH_PKB	32..126	CDD:269947	5/22 (23%)
		PH	35..121	CDD:278594	5/17 (29%)
		S_TKc	167..424	CDD:214567	122/260 (47%)
		STKc_PKB_beta	171..493	CDD:173686	149/326 (46%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100157
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810