DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment S6k and Akt1

DIOPT Version :9

Sequence 1:	NP_001261450.1	Gene:	S6k / 38654	FlyBaseID:	FBgn0283472	Length:	490	Species:	Drosophila melanogaster
Sequence 2:	NP_150233.1	Gene:	Akt1 / 24185	RGDID:	2081	Length:	480	Species:	Rattus norvegicus

Alignment Length:	357	Identity:	154/357 - (43%)
Similarity:	219/357 - (61%)	Gaps:	13/357 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly    51 DTEGQETIQLCEENVNPGKIKLGPKDFELKKVLGKGGYGKVFQVRKTAGRDANKYFAMKVLKKAS 115
            |..|.|.:::.   :...|.::...:||..|:||||.:|||..|::.|   ..:|:|||:|||..
  Rat   127 DNSGAEEMEVA---LAKPKHRVTMNEFEYLKLLGKGTFGKVILVKEKA---TGRYYAMKILKKEV 185

  Fly   116 IVTNQKDTAHTRAERNILEAVKHPFIVELVYAFQTDGKLYLILEYLSGGELFMHLEREGIFLEDT 180
            ||. :.:.|||..|..:|:..:|||:..|.|:|||..:|..::||.:|||||.||.||.:|.||.
  Rat   186 IVA-KDEVAHTLTENRVLQNSRHPFLTALKYSFQTHDRLCFVMEYANGGELFFHLSRERVFSEDR 249

  Fly   181 TCFYLSEIILALGHLH-KLGIIYRDLKPENILLDAQGHVKLTDFGLCKEHIQEGIVTHTFCGTIE 244
            ..||.:||:.||.:|| :..::|||||.||::||..||:|:||||||||.|::|....|||||.|
  Rat   250 ARFYGAEIVSALDYLHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGIKDGATMKTFCGTPE 314

  Fly   245 YMAPEILTRSGHGKAVDWWSLGALMFDMLTGVPPFTAENRKKTIETILKAKLNLPAYLTPEARDL 309
            |:|||:|..:.:|:|||||.||.:|::|:.|..||..::.:|..|.||..::..|..|.|||:.|
  Rat   315 YLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELILMEEIRFPRTLGPEAKSL 379

  Fly   310 VRRLMKRQEPQRLGSGPEDAAAVQIHPFFKHVNWDDVLARRLEPPIKPLLRSEDDVSQFDTRFTR 374
            :..|:|:...||||.|.|||..:..|.||.::.|.||..::|.||.||.:.||.|...||..||.
  Rat   380 LSGLLKKDPTQRLGGGSEDAKEIMQHRFFANIVWQDVYEKKLSPPFKPQVTSETDTRYFDEEFTA 444

  Fly   375 QI----PVDSPDDTTLSESANL-IFQGFTYVA 401
            |:    |.|..|.....:|... .|..|:|.|
  Rat   445 QMITITPPDQDDSMECVDSERRPHFPQFSYSA 476

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
S6k	NP_001261450.1	PTZ00263	76..397	CDD:140289	147/326 (45%)
S6k	NP_001261450.1	STKc_p70S6K	81..402	CDD:270736	148/327 (45%)
Akt1	NP_150233.1	PH_PKB	4..111	CDD:269947
		Inositol-(1,3,4,5)-tetrakisphosphate binding. /evidence=ECO:0000250	14..19
		Inositol-(1,3,4,5)-tetrakisphosphate binding. /evidence=ECO:0000250	23..25
		STKc_PKB_alpha	124..479	CDD:270746	154/357 (43%)
		Inhibitor binding. /evidence=ECO:0000250	228..230		1/1 (100%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	451..480		8/26 (31%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100157
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810