DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment S6k and AKT1

DIOPT Version :9

Sequence 1:	NP_001261450.1	Gene:	S6k / 38654	FlyBaseID:	FBgn0283472	Length:	490	Species:	Drosophila melanogaster
Sequence 2:	NP_001014431.1	Gene:	AKT1 / 207	HGNCID:	391	Length:	480	Species:	Homo sapiens

Alignment Length:	357	Identity:	154/357 - (43%)
Similarity:	217/357 - (60%)	Gaps:	13/357 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly    51 DTEGQETIQLCEENVNPGKIKLGPKDFELKKVLGKGGYGKVFQVRKTAGRDANKYFAMKVLKKAS 115
            |..|.|.:   |.::...|.::...:||..|:||||.:|||..|::.|   ..:|:|||:|||..
Human   127 DNSGAEEM---EVSLAKPKHRVTMNEFEYLKLLGKGTFGKVILVKEKA---TGRYYAMKILKKEV 185

  Fly   116 IVTNQKDTAHTRAERNILEAVKHPFIVELVYAFQTDGKLYLILEYLSGGELFMHLEREGIFLEDT 180
            ||. :.:.|||..|..:|:..:|||:..|.|:|||..:|..::||.:|||||.||.||.:|.||.
Human   186 IVA-KDEVAHTLTENRVLQNSRHPFLTALKYSFQTHDRLCFVMEYANGGELFFHLSRERVFSEDR 249

  Fly   181 TCFYLSEIILALGHLH-KLGIIYRDLKPENILLDAQGHVKLTDFGLCKEHIQEGIVTHTFCGTIE 244
            ..||.:||:.||.:|| :..::|||||.||::||..||:|:||||||||.|::|....|||||.|
Human   250 ARFYGAEIVSALDYLHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGIKDGATMKTFCGTPE 314

  Fly   245 YMAPEILTRSGHGKAVDWWSLGALMFDMLTGVPPFTAENRKKTIETILKAKLNLPAYLTPEARDL 309
            |:|||:|..:.:|:|||||.||.:|::|:.|..||..::.:|..|.||..::..|..|.|||:.|
Human   315 YLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELILMEEIRFPRTLGPEAKSL 379

  Fly   310 VRRLMKRQEPQRLGSGPEDAAAVQIHPFFKHVNWDDVLARRLEPPIKPLLRSEDDVSQFDTRFTR 374
            :..|:|:...||||.|.|||..:..|.||..:.|..|..::|.||.||.:.||.|...||..||.
Human   380 LSGLLKKDPKQRLGGGSEDAKEIMQHRFFAGIVWQHVYEKKLSPPFKPQVTSETDTRYFDEEFTA 444

  Fly   375 QI----PVDSPDDTTLSESANL-IFQGFTYVA 401
            |:    |.|..|.....:|... .|..|:|.|
Human   445 QMITITPPDQDDSMECVDSERRPHFPQFSYSA 476

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
S6k	NP_001261450.1	PTZ00263	76..397	CDD:140289	146/326 (45%)
S6k	NP_001261450.1	STKc_p70S6K	81..402	CDD:270736	147/327 (45%)
AKT1	NP_001014431.1	PH_PKB	4..111	CDD:269947
		Inositol-(1,3,4,5)-tetrakisphosphate binding	14..19
		Inositol-(1,3,4,5)-tetrakisphosphate binding	23..25
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	113..138		4/13 (31%)
		STKc_PKB_alpha	124..479	CDD:270746	154/357 (43%)
		Inhibitor binding	228..230		1/1 (100%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	450..480		8/27 (30%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100157
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R469
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.840