DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment S6k and rsks-1

DIOPT Version :9

Sequence 1:	NP_001261450.1	Gene:	S6k / 38654	FlyBaseID:	FBgn0283472	Length:	490	Species:	Drosophila melanogaster
Sequence 2:	NP_499447.2	Gene:	rsks-1 / 176554	WormBaseID:	WBGene00012929	Length:	550	Species:	Caenorhabditis elegans

Alignment Length:	529	Identity:	275/529 - (51%)
Similarity:	349/529 - (65%)	Gaps:	60/529 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MADVSDPSELFDLELHDLELQ--------DDKARDSDDDRI--ELDDVDLEPELCINLHQDTEGQ 55
            ||||.:    |:||.|:.:..        |:.....:||.:  .:.|..:......:.:.:....
Worm     1 MADVFE----FELEGHESQASPQRHAYHYDNCTEIMEDDHMYSNVADGQISAPPPSSSYMEDPMM 61

  Fly    56 ETIQLCEENVNPGKIKLGPKDFELKKVLGKGGYGKVFQVRKTAGRDANKYFAMKVLKKASIVTNQ 120
            |:||||...:||..:::||:||:|.|||||||||||||||||.|.|..:.||||||:||:||.||
Worm    62 ESIQLCASAINPPNVRVGPEDFQLLKVLGKGGYGKVFQVRKTTGSDNGQIFAMKVLQKATIVRNQ 126

  Fly   121 KDTAHTRAERNILEAVKHPFIVELVYAFQTDGKLYLILEYLSGGELFMHLEREGIFLEDTTCFYL 185
            ||||||:||||||||||.|||.:|:|||||.|||||||||||||||||||||||:|:|:...|||
Worm   127 KDTAHTKAERNILEAVKSPFICDLLYAFQTGGKLYLILEYLSGGELFMHLEREGMFMENVAKFYL 191

  Fly   186 SEIILALGHLHKLGIIYRDLKPENILLDAQGHVKLTDFGLCKEHIQEGIVTHTFCGTIEYMAPEI 250
            |||:::|.|||:.||||||||||||||||.|||||||||||||.|:....|||||||||||||||
Worm   192 SEIVVSLEHLHQQGIIYRDLKPENILLDAYGHVKLTDFGLCKEEIEGDQKTHTFCGTIEYMAPEI 256

  Fly   251 LTRSGHGKAVDWWSLGALMFDMLTGVPPFTAENRKKTIETILKAKLNLPAYLTPEARDLVRRLMK 315
            |.|.|||||||||||||||||||||.||||||||:|||:.|||.:|.|||||:.|||||:::|:|
Worm   257 LMRCGHGKAVDWWSLGALMFDMLTGGPPFTAENRRKTIDKILKGRLTLPAYLSNEARDLIKKLLK 321

  Fly   316 RQEPQRLGSGPEDAAAVQIHPFFKHVNWDDVLARRLEPPIKPLLRSEDDVSQFDTRFTRQIPVDS 380
            |....|||:|..||..::.|.|||..:|:.|.||:||.|.||.:.:::|.|.||.|||:..||||
Worm   322 RHVDTRLGAGLSDAEEIKSHAFFKTTDWNLVYARQLEAPFKPNIENDEDTSLFDARFTKMTPVDS 386

  Fly   381 PDDTTLSESANLIFQGFTYVAPSILEDM-----------HRANRMPARSPRRTPRQLPDSSFRLQ 434
            |.:|..|.:.:..|.||||||||:||.|           |.|:.|......::||:..|..
Worm   387 PCETNFSLNGDNPFVGFTYVAPSVLEMMNKGGHGGISVAHLASSMSRAGAAKSPRKPGDPE---- 447

  Fly   435 FPSANV--GANAPLAMHGHSQRS------GMFARAT----------PPHH-----------MQTF 470
              :|::  |.::.|..||.:..:      |:.::.|          .|:.           |.|.
Worm   448 --TASILHGGHSNLFGHGPNSEAPQAFGYGIGSQMTTTTAGGAGIQQPYQSFSGGYPEDDAMDTS 510

  Fly   471 APRPSPAQD 479
            .||.|.:::
Worm   511 TPRASESRE 519

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
S6k	NP_001261450.1	PTZ00263	76..397	CDD:140289	224/320 (70%)
S6k	NP_001261450.1	STKc_p70S6K	81..402	CDD:270736	226/320 (71%)
rsks-1	NP_499447.2	S_TKc	83..344	CDD:214567	196/260 (75%)
rsks-1	NP_499447.2	STKc_p70S6K	86..408	CDD:270736	226/321 (70%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160157812
Domainoid	1	1.000	401	1.000	Domainoid score	I368
eggNOG	1	0.900	-	-		E1_KOG0598
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H81703
Inparanoid	1	1.050	502	1.000	Inparanoid score	I746
Isobase	1	0.950	-	0	Normalized mean entropy	S756
OMA	1	1.010	-	-		QHG51952
OrthoDB	1	1.010	-	-		D1132245at2759
OrthoFinder	1	1.000	-	-		FOG0001793
OrthoInspector	1	1.000	-	-		oto19658
orthoMCL	1	0.900	-	-		OOG6_100157
Panther	1	1.100	-	-	LDO	PTHR24351
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R469
SonicParanoid	1	1.000	-	-		X1494
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	17	16.750