DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment S6k and rskn-1

DIOPT Version :9

Sequence 1:	NP_001261450.1	Gene:	S6k / 38654	FlyBaseID:	FBgn0283472	Length:	490	Species:	Drosophila melanogaster
Sequence 2:	NP_001122504.1	Gene:	rskn-1 / 172647	WormBaseID:	WBGene00011352	Length:	804	Species:	Caenorhabditis elegans

Alignment Length:	429	Identity:	197/429 - (45%)
Similarity:	267/429 - (62%)	Gaps:	46/429 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 SDPSELFDLELHDLE--------LQDDKARDSDDDRIELDDVDLEPELCINLHQDTEGQETIQLC 61
            ||.:..|...:|.::        |.:.|...|.:..|::.||                    :.|
Worm    45 SDTTNTFHSSIHIIQPPPNNGFRLMNWKTDSSSETEIDIGDV--------------------RKC 89

  Fly    62 EENVNPGKIKLGPKDFELKKVLGKGGYGKVFQVRKTAGRDANKYFAMKVLKKASIVTNQKDTAHT 126
            .|       |..|:.|||.||||:|.:||||.|||..|||:...:||||||||::  ..:|...|
Worm    90 GE-------KADPRQFELLKVLGQGSFGKVFLVRKVRGRDSGHVYAMKVLKKATL--KVRDRQRT 145

  Fly   127 RAERNILEAVKHPFIVELVYAFQTDGKLYLILEYLSGGELFMHLEREGIFLEDTTCFYLSEIILA 191
            :.|||||..:.|||||:|.|||||:|||||||::|.||:||..|.:|.:|.||...|||:|:.||
Worm   146 KLERNILAHISHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEDDVKFYLAELTLA 210

  Fly   192 LGHLHKLGIIYRDLKPENILLDAQGHVKLTDFGLCKEHIQEGIVTHTFCGTIEYMAPEILTRSGH 256
            |.|||.|||:|||||||||||||.||:|:|||||.||.|.....|::||||:||||||::.|.||
Worm   211 LEHLHSLGIVYRDLKPENILLDADGHIKVTDFGLSKEAIDSEKKTYSFCGTVEYMAPEVINRRGH 275

  Fly   257 GKAVDWWSLGALMFDMLTGVPPFTAENRKKTIETILKAKLNLPAYLTPEARDLVRRLMKRQEPQR 321
            ..|.|:||||.|||:||||..||...:|..|:..||||||::|.:||.||:.|:|.|.||....|
Worm   276 SMAADFWSLGVLMFEMLTGHLPFQGRDRNDTMTQILKAKLSMPHFLTQEAQSLLRALFKRNSQNR 340

  Fly   322 LGSGPEDAAAVQIHPFFKHVNWDDVLARRLEPPIKPLLRSEDDVSQFDTRFTRQIPVDSPDDTTL 386
            ||:||:....::.|.||..:::..:|.:.::||.||.|.:.|..|.||..||::.|.|||   .|
Worm   341 LGAGPDGVEEIKRHAFFAKIDFVKLLNKEIDPPFKPALSTVDSTSYFDPEFTKRTPKDSP---AL 402

  Fly   387 SESAN--LIFQGFTYVAPSILEDMHRANRMPARSPRRTP 423
            ..|||  .||:||::|:.:::|:    .::.|:|.|..|
Worm   403 PASANGHEIFRGFSFVSNAVMEE----RKLIAKSVRSVP 437

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
S6k	NP_001261450.1	PTZ00263	76..397	CDD:140289	175/322 (54%)
S6k	NP_001261450.1	STKc_p70S6K	81..402	CDD:270736	175/322 (54%)
rskn-1	NP_001122504.1	S_TKc	98..357	CDD:214567	151/260 (58%)
		STKc_RSK_N	102..418	CDD:270734	174/320 (54%)
		STKc_RSK_C	447..744	CDD:270993
		S_TKc	448..706	CDD:214567
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1132245at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R469
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.950