DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment S6k and rskn-2

DIOPT Version :9

Sequence 1:	NP_001261450.1	Gene:	S6k / 38654	FlyBaseID:	FBgn0283472	Length:	490	Species:	Drosophila melanogaster
Sequence 2:	NP_001348666.1	Gene:	rskn-2 / 172581	WormBaseID:	WBGene00008311	Length:	773	Species:	Caenorhabditis elegans

Alignment Length:	352	Identity:	155/352 - (44%)
Similarity:	228/352 - (64%)	Gaps:	12/352 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly    62 EENVNPGKIKLGPKDFELKKVLGKGGYGKVFQVRKTAGRDANKYFAMKVLKKASIVTNQKDTAHT 126
            |:.:.|...|:..::|.|.:|||||.|||||.|||..|:|.|..:|||||:|..::|.||...||
Worm     2 EDILMPEGEKVSMENFALLRVLGKGAYGKVFLVRKVGGKDHNTIYAMKVLRKTRVLTKQKTLEHT 66

  Fly   127 RAERNILEAVK-HPFIVELVYAFQTDGKLYLILEYLSGGELFMHLEREGIFLEDTTCFYLSEIIL 190
            .|||.:||.:: .||:|.|.||||||.||::::||:.|||||.||...|.|..:...|.::|:::
Worm    67 MAERQVLERLRGTPFLVNLFYAFQTDTKLHIVMEYVRGGELFTHLCSRGHFDLEAARFVIAELVV 131

  Fly   191 ALGHLHKLGIIYRDLKPENILLDAQGHVKLTDFGLCKEHIQ-EGIVTHTFCGTIEYMAPEILTR- 253
            |:..||:..:||||||.||||||.:||||||||||.|..:. |....:::|||||||:||::.|
Worm   132 AIDSLHQRKVIYRDLKLENILLDEEGHVKLTDFGLSKLFLPGELDRANSYCGTIEYMSPEVINRP 196

  Fly   254 -SGHGKAVDWWSLGALMFDMLTGVPPFT---AENRKKTI-ETILKAKLNLPAYLTPEARDLVRRL 313
             .|:...|||||||.:.|::|||..|||   |:|..|.| :.|:..|:..|..:..:|||.:.:|
Worm   197 EGGYSDVVDWWSLGVISFELLTGCSPFTVDGAQNSSKDIAKRIMTKKVPFPKTMDVDARDFIGQL 261

  Fly   314 MKRQEPQRLGSGPEDAAAVQIHPFFKHVNWDDVLARRLEPPIKPLLRSEDDVSQFDTRFTRQIPV 378
            ::::..:|||....|  .::.|.|...::||..:.|.|:|.|.|.:..:.|...|...||.|.|:
Worm   262 LEKKLEKRLGYNGVD--EIKNHKFMSSIDWDAAVKRTLKPVIVPRIGHDLDTQFFSAEFTSQPPL 324

  Fly   379 DSPDDTTLSESANLIFQGFTYVAPSIL 405
            .||.::.|  :||.:|:|::||:||::
Worm   325 YSPAESPL--NANTLFRGYSYVSPSVI 349

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
S6k	NP_001261450.1	PTZ00263	76..397	CDD:140289	147/328 (45%)
S6k	NP_001261450.1	STKc_p70S6K	81..402	CDD:270736	148/328 (45%)
rskn-2	NP_001348666.1	PKc_like	22..287	CDD:328722	126/266 (47%)
		S_TK_X	285..344	CDD:214529	20/60 (33%)
		STKc_MSK_C	374..694	CDD:270994
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1132245at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R469
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.950